| ObjectivesOur purpose is to explore the relationship between serum uric acid(SUA),serum albumin(SA)levels and hypertension(HTN),prehypertension(PHT)among middle-aged and elderly women in China and provide scientific theoretical basis and guidance for the targeted development of HTN control in the futureMethodsThis study uses the 2009 baseline data from the China Health and Nutrition Survey Database(CHNS),a cross-sectional study.There were 3634 subjects in this study.According to HTN and PHT diagnostic standards,our study subjects were divided into normal blood pressure group,HTN and PHT group.According to the quartiles of SUA?SA levels,the research objects were divided into 4 groupsFor classified data,the composition ratio is used for comparative analysis,and the comparison between groups is tested by chi-square.For quantitative data,if the sample population obeys the normal distribution and meets the homogeneity of variance,we use the analysis of variance for comparison between groups.For those that do not meet the above conditions,we use the nonparametric statistical method Kruskal-Wallis test.This study used a restricted cubic spline method to investigate whether there is a non-linear relationship between SUA and SA levels and HTN and PHT risk.We constructed multi-class logistic regression models to estimate the Odds ratio(OR)of SUA and SA quartiles to the prevalence of HTN and PHT.In all main analyses,<3.58 mg/dl was used as the reference group in the four subgroups of SUA;?42.60 g/1 was used as the reference group in the four subgroups of SA.We further explored the correlation between SUA,SA and HTN and PHT in women of different ages.In order to test the stability of the analysis model of this study,we kept only non-obese,normal blood glucose and normal blood lipid subjects,and performed multi-class Logistic regression analysis again.In order to explore the relationship between SUA and HTN and SA and HTN in more depth,we conducted an interaction analysis.The interactions of hyperuricemia(HUA),SA with diabetes(DM),obesity,and dyslipidemia were analyzed separatelyAll statistical analyses performed in this study were performed using IBM SPSS Statistics 24.0 software(SPSS Inc.,Chicago,IL)and STATA 1 5.0(Stata Corporation,College Station,TX,USA).We consider p<0.05 as statistically significant(?=0.05)Results1.A total of 3634 women were included in this study,of which 1,217 women had normal blood pressure,accounting for 33.50%of the total;1,417 women had PHT,accounting for 39.00%;and 1,000 had HTN,accounting for 27.50%.Hyperuricemia was diagnosed in 484 women,accounting for 11.60%2.The results of multiple linear regression analysis showed that SUA was positively correlated with female Systolic pressure(SBP)and Diastolic pressure(DBP)(P=0.01,p=0.01);SA was positively correlated with female SBP and DBP(P=0.01,p<0.01)3.Restricted cubic spline results showed that SUA levels and SA were linearly related to the risk of HTN and PHT.Under increasing SUA levels,the OR value of PHT showed a linear trend(?2=363.66,P trend<0.01),and HTN also showed a linear trend(?2=858.22,P trend<0.01),the results were not statistically significant.At high levels of SA,the OR of PHT has a linear trend(?2=279.95,P trend<0.001),and HTN also has a linear trend(?2=877.96,P trend<0.01),the results were not statistically significant4.Multivariate non-conditional Logistic regression analysis results showed that SUA levels with highest quartile women having 1.46 times risk of HTN compared with reference group;SUA levels with highest quartile(>5.25mg/dl)women having 1.40 times the risk of PHT compared with reference group;women's SA levels in the highest quartiles(>46.8mg/dl)and third quartiles(44.8-46.8mg/dl)had a higher risk of HTN(OR=1.63,95%CI:1.20-2.22;OR=1.76,95%CI:1.33-2.33)compared with those in the first quartiles;women's SA levels with third quartile(44.80-46.80mg/dl)had a higher risk of PHT(OR=1.38,95%CI:1.09-1.75)compared with those in the first quartiles.5.The correlation analysis of SUA and SA with HTN and PHT in women of different ages and show that,in the<45 years old age group,the risk of HTN in the highest SA concentration group and the third dose level group is 2.38 times and 2.07 times compared with the reference group;in the age group of 45-55 years,the risk of PHT in the highest concentration group of SA is 2.04 times that of the reference group,and the risk of HTN in the highest concentration group of SUA is 1.79 times that of the reference group;in the age group>55 years,the risk of HTN in the third dose of SA group was 1.93 times that of the reference group,the risk of HTN in the highest SUA concentration group was 2.22 times that of the reference group,and the risk of PHT in the highest SUA concentration group was 1.83 times that of the reference group.6.The results of the sensitivity analysis show that women with high SUA levels(?5.25mg/dl)having 1.78 times to develop HTN than the first quantile.Women's SA levels with fourth quartiles(>46.80mg/dl)and third quartiles(44.8-46.8mg/dl)had a higher risk of HTN(OR:1.79 95%CI:1.20 to 2.67;OR:1.64 95%Cl:1.14 to 2.37)compared with those in the first quartiles;Women in the fourth and third quartile had a higher risk of PHT(OR:1.42 95%CI:1.06 to 1.89;OR:1.46 95%CI:1.07 to 1.99)compared with those in the first quartiles.7.After adjusting for confounding factors,the results show that in the additive interaction of HUA and obesity,S=1.39,RERI=1.68,AP=24%;in the additive interaction of HUA and DM,S=0.69,RERI=-0.40.AP=-12%;in the additive interaction of HUA and dyslipidemia,S=0.84,RERI=-0.40,AP=-12%,the addition and multiplication interaction results were not statistically significant.8.After adjusting for confounding factors,the results show that in the additive interaction of SA and obesity,the results show S=0.91,RERI=-0.48.AP=-7%;in the additive interaction of SA and DM,S=0.36,RERI=-1.35,AP=-75%;in the additive interaction of SA and dyslipidemia,S=1.04,RERI=0.05,AP=2%,The addition and multiplication model interaction results were not statistically significant.Conclusion1.This study is based on a nationwide population of women.The prevalence of HTN and the prevalence of HUA has an increasing trend with age,and the prevalence of PHT has also increased in the middle-aged and elderly female population.Therefore,in the early screening and prevention of hypertension,attention should be paid to the situation of middle-aged and elderly women.2.This study further proved the positive correlation between high SUA levels and PHT and HTN.and found a linear dose-response relationship between SUA and PHT and HTN,suggesting that an increase in SUA levels not only increases the risk of HTN,but also increases HTN early occurrence risk.3.In addition,this study found that there is a dose-response relationship between SA levels and PHT and HTN in female populations.Increased SA concentrations have a positive correlation with PHT and HTN.Increased SA levels not only increase the risk of HTN,but also increase the PHT risk.4.This study suggests that special attention should be paid to the blood pressure of women and the levels of SUA and SA;and it can provide some theoretical basis and guidance for the early screening and control of HNT in women. |
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