Study On The Relationship Between 25-hydroxyvitamin D3 And Type 2 Diabetic Peripheral Neuropathy

ObjectiveTo investigate the relationship between 25-hydroxyvitamin D3[25(OH)D3]and type 2 diabetic peripheral neuropathy(DPN).MethodsAccording to the retrospective analysis of clinical data collected from 46 patients with type 2 diabetes,those patients were divided into DPN group(with peripheral neuropathy)and NDPN group(with type 2 diabetes alone).The levels of 25(OH)D3 were compared between two groups along with the course of disease,age,fasting blood glucose,glycosylated hemoglobin and other related indexes.Results(1)The 25(OH)D3 level in the DPN group was(18.27±4.48)ng/mL,which was lower than the level in NDPN group(24.55±6.68)ng/mL(P<0.05);(2)There was no significant correlation observed between the 25(OH)D3 level and the patient's course of disease,age,and glycosylated hemoglobin level(P>0.05).(3)The independent variables of type 2 diabetic peripheral neuropathy were age,glycosylated hemoglobin,course of disease,and serum 25-hydroxyvitamin D3.Among them,the glycosylated hemoglobin and the course of disease were negatively correlated,and the serum 25-hydroxyvitamin D3 was positively correlated,showing a noteworthy statistical significance(P<0.05).ConclusionThe serum 25-hydroxyvitamin D3 level in patients with type 2 diabetic peripheral neuropathy is lower than that in patients with type 2 diabetes mellitus alone,and the serum 25-hydroxyvitamin D3 is closely correlated with type 2 diabetic peripheral neuropathy.Low serum 25-hydroxyvitamin D3 is a risk factor for type 2 diabetic peripheral neuropathy.