Association Between Serum 25-hydroxyvitamin D And Peripheral Neuropathy In Type 2 Diabetes

Objective: The aim of this study was to investigate the serum 25(OH)D concentrations in the patients with type 2 diabetes mellitus(T2DM),to explore the relevance between vitamin D levels and diabetic peripheral neuropathy(DPN),and further to provide a new idea for early clinical prevention and treatment of DPN.Methods: A total of 202 patients with type 2 diabetes(T2DM)who were admitted to the Department of Endocrinology from January 2017 to December 2017 were enrolled in the experiment.The patients were divided into DPN group(n=101)and NDPN group(n=101).The basic clinical information,biochemical indicators,serum 25(OH)D,and other parameters were collected in all patients.The items of two groups were compared.The influencing factors of vitamin D were explored by single factor and multi-factor linear regression analysis.The effects of various factors on disease of DPN were investigated by binary logistic regression analysis.Results: The DPN group had significantly lower serum 25(OH)D concentration(13.75±6.27ng/mL)and higher prevalence of vitamin D deficiency(86.1%)than the NDPN group(16.26±7.36ng/mL;70.3%)(<0.05),HbA1 c and 24 hMAU were negativelycorrelated with serum 25(OH)D level(<0.05).The serum ionic calcium was positivelycorrelated with serum 25(OH)D level(<0.05).Binary Logistic regression analysisindicated that serum 25(OH)D levels were significantly associated with DPN(<0.05),25(OH)D was the protective factor of DPN(OR 0.953),FPG and the course of T2 DM were Risk factor of DPN.Conclusion: DPN population has lower vitamin D levels and higher prevalence of vitamin D deficiency.Patients with T2 DM who have insufficient vitamin D may increase the risk of developing DPN.