| Objective:In this study,the ultrasound bone mineral density Z value of 1-3 month-old young infantsand lactating mothers 25-(OH)D level were measured and compared with the young infant’s gender,parity,production mode,sunshine time,vitamin D supplementation and lactating mother’s age,calcium nutrition status,ethnicity,education level,sunshine time,etc.To understand the correlation between bone mineral density of young infants in Kunming and calcium nutrition status of lactating mothers,aiming to understand the relationship between ultrasound bone mineral density of young infants in plateau area and 25-(OH)D level of lactating mothers,To provide a basis for the necessity of calcium supplementation for lactating mothers in Kunming.Methods:Using prospective research methods,60 cases of exclusively breastfed young infants and their lactating mothers who were followed up in the Children’s Health Clinic of the Second Affiliated Hospital of Kunming Medical University from February 2019 to December 2019 were used as research subjects.According to the bone mineral density Z value of infants,it is divided into 2 groups(normal bone density group,low or insufficient bone density group),according to the level of 25-(OH)D of breastfeeding mothers,they were divided into 2 groups(25-(OH)D normal group,25-(OH)D is insufficient or lack of group).All young infants were measured for ultrasound bone mineral density,and the lactating mothers were tested for serum 25-(OH)D,Ca,and P levels,and a questionnaire survey was conducted The bone mineral density of young infants was detected by ultrasonic quantitative detection,serum 25-(OH)D level detected by chemiluminescence immunoassay,and Ca and IP were detected by indirect ion selection method.Statistical analysis was performed on the data using SPSS 17.0 statistical software.Results:1.Among 60 young infants,12 cases in the normal bone density group accounted for 20%;48 cases in the group with low or insufficient bone density accounted for 80%.The average z-value of bone density in young infants is:-1.10.2.There is no statistically significant difference in bone density of young infants between different parity,mode of production,birth comorbidity,age,and duration of sunshine.The P values respectively were:0.598,0.542,0.470,0.386,0.389.The bone mineral density of young infants was compared between different genders and vitamin D supplementation,the difference was statistically significant,the P values respectively were:0.002,0.035.The binary classification logistics regression analysis showed that women are the risk factors for normal bone mineral density(OR=8.64,95%CI=1.65-45.22),and vitamin D supplementation is the protective factor for normal bone mineral density(OR=0.52,95%CI=0.23-0.83).3.60 cases of lactating mothers with normal 25-(OH)D level were 35 cases,accounting for 58.3%,25-(OH)D level is insufficient and lack of were 25 cases,accounting for 41.7%.The average number of 25-(OH)D levels of lactating mothers is:23.16ng/ml.4.The 25-(OH)D level of lactating mothers is not statistically different between different nationalities,education levels,whether regular vitamin D supplementation,regular calcium supplementation,and pregnancy complications are found.the P values respectively were:0.513,0.757,0.650,0.314,0.775.The 25-(OH)D levels of lactating mothers were compared between different sunshine hours and ages,and the differences were statistically significant.The P values were all 0.044,and the 25-(OH)D levels are lower in lactating mothers of the sunshine hours<2h compared with the sunshine hours≥2h;25-(OH)D levels are lower in lactating mothers≥35 years old than those<35 years old.5.Comparing the 25(OH)D levels of lactating mothers with Ca and P,the serum Ca levels of the normal and abnormal 25-(OH)D levels were:2.39 ± 0.09mmol/l,2.36 ± 0.11 mmol/l,the serum P levels were1.38 ± 0.18mmol/l and 1.3 ± 0.14mmol/l.The normal group was higher than the abnormal group,but the difference was not statistically significant.The P values respectively were0.257 and 0.116.6.There was no statistically significant difference between the bone density of young infants and lactating mothers at different ages,education levels,whether regular vitamin D supplementation,regular calcium supplementation,and pregnancy comorbidities.The P values respectively were:0.104,0.190,0.136,0.638,0.260.There was no statistically significant difference between the bone density of young infants and the Ca and P of lactating mothers.The serum Ca levels of normal and abnormal BMD mammary groups were:2.37±0.11mmol/l,2.38±0.10mmol/l,and the serum P levels were:1.34±0.21.mmol/l,1.35±0.16mmol/l,the P values respectively were:0.607,0.874.7.The difference between the bone density of young infants and the nationality of lactating mothers and 25-(OH)D is statistically significant.The P values respectively were 0.036 and 0.001.Infants of Han nationality lactating mothers are more likely to suffer from insufficient bone mineral density.The lactating mothers in the normal bone mineral density group have higher 25-(OH)D levels.The lactating mothers in the normal and abnormal bone density groups have 25-(OH)D levels respectively were 25.08±3.45ng/ml and 19.55±5.16ng/ml.Conclusion(s):1.In this study,small infants generally have low or insufficient bone mineral density.Female infants are a risk factor for normal bone mineral density,and vitamin D supplementation is a protective factor for normal bone mineral density2.The level of 25-(OH)D of lactating mothers in this stuty is low,41.7%is inadequate or lacking,and the time of sunshine ≥ 2h is higher than that of breasting mothers with<2h of sunshine;25-(OH)D levels of lactating mothers≥35 years old are lower than those of<35 years old.3.Bone mineral density in young infants is related to the nationality of the lactating mothers and 25-(OH)D level.Young infants of Han nationality lactating infants are more likely to suffer from insuficienft bone mineral density,and young infants with normal bone mineral density have higher lactating 25-(OH)D levels. |
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