Analysis Of Vaginal Microecological Characteristics Of 124 HIV Infected Women

Objective:In order to provide reference and basis for clinical diagnosis and treatment,the vaginal microecological characteristics of 124 HIV women were analyzed to explore the relationship between HIV infection and vaginal microecological imbalance and vaginal infectionMethods:From December 2018 to December 2019,124 HIV female patients aged 20-42 who came to the third people's Hospital of Kunming City,Yunnan Province were recruited to fill in the knowledge questionnaire of the research project on vaginal microecology of HIV female patients.Take the secretion from posterior vault of vagina and upper 1/3 of vagina,detect the structure,species and density of bacteria in the secretion,and analyze the results.(1)To study the influence of different factors on the rate of vaginal microecological imbalance in women with HIV,such as age,annual family income level,whether to smoke,whether to have children,the number of male sexual partners,the number of sexual life in the past month,whether to use condoms in sexual life and whether to use antibiotics in the past two weeks,the number of CD4+T cell,HIV load,antiviral treatment time,etc.(2)The number of CD4+T cell,HIV viral load and anti HIV treatment time are important indicators for the diagnosis of HIV patients.This paper will study the characteristics of vaginal microecology in different patients from these aspects(3)To study the relationship between the predominance of lactobacilli in vagina and vagina infection(BV,AV,VVC,vagina mixed infection),and analyze the correlation between them.Results:(1)The average age of 124 women with HIV was(35.26±4.54)years old,including 57 patients with vaginal microecology balance and 67 patients with vaginal microecology imbalance.The imbalance rate of vaginal microecology was not related to age,family income,education level,smoking,fertility,number of male sexual partners,number of sexual life in the past month,condom use in sexual life and antibiotic use in the past two weeks(P>0.05).(2)The number of CD4+T cells ?350/?L in 124 HIV women was 25,and the number of CD4+T cells>350/?L was 99.The high diversity of vaginal flora(grade ?/?/?),pH>4.5,imbalance of vaginal microecology and BV infection in patients with CD4+T cell value>350/?L were significantly lower than those in patients with CD4+T cell value ?350/?L(P<0.05).However,there was no significant difference between the two groups(P>0.05).(3)There were 115 HIV patients with 0 copies/ml and 6 with 1-100 copies/ml in 121 HIV women.There was no significant difference between the two groups(P>0.05).(4)Among 116 HIV female patients,13 patients had antiviral treatment time of less than 3 years,39 patients had antiviral treatment time of 3-5 years,66 patients had antiviral treatment time of more than 5 years.There were no significant differences among the three groups in terms of vaginal cleanliness,dominant flora,diversity of flora,pH value,leukocyte esterase,sialidosidase and vaginal mixed infection rate(P>0.05).The bacterial density of patients with treatment time>5 years(grade ? and ?)was significantly higher than that of patients with treatment time of 3-5 years(x 2=9.264,P=0.009),the difference was statistically significant.(5)Among 124 HIV infected female patients,71 were predominant and 53 were non dominant.There was no significant difference in BV infection rate between the two groups(P>0.05).The infection rate of BV,AV and vagina in the predominance group was significantly lower than that in the non predominance group(P<0.05).Conclusion:(1)The vaginal microecological balance of HIV women is affected by the level of CD4+T cells.The higher CD4+T cell value is the protective factor of vaginal microecological balance.For the patients whose CD4+T cells are less than 350/?L,the imbalance of vaginal microecology and the risk of BV infection are increased.(2)Increasing the content of Lactobacillus in vagina is beneficial to maintain the micro ecological balance of vagina and reduce the risk of vagina infection.In order to provide reference for the diagnosis and treatment and prevention of the imbalance of vaginal microecology and vaginal infection in the future,which is conducive to the maintenance of the health of women with HIV.