The Prevalence And Associated Risk Factors Of Early-onset Stroke

Background:In recent years,stroke patients gradually get younger,and the incidence of early-onset stroke is increasing.The early-onset stroke not only seriously threatens the health of residents,but also intensifies the social and economic burden,which has become a major public health problem.Therefore,the prevalence and high-risk factors of early-onset stroke in Changzhou should be determined to provide epidemiological basis for the prevention and treatment of stroke.Methods:This retrospective study included 821 hospitalized stroke patients from the First People's Hospital of Changzhou.Each participant was performed questionnaire for collecting lifestyle and sociodemographic information,anthropometric measurements and blood sampling.Early-onset stroke was defined as the stroke occurred first time at 50 years old or younger.Results:1.Among all stroke patients,98(11.9%)were early-onset stroke patients.Compared to late-onset stroke patients,those with early-onset stroke had more proportion of males and hyperlipidemia,but lower proportion of primary and lower education,no smoking,current drinker,and history of heart disease and use of antihypertensive and antidiabetic agents.Additionally,early-onset stroke patients,compared with the late-onset stroke patients,had higher levels of BMI,DBP,TC,TG and LDL-c,but lower levels of FPG,SBP and Hcy.(all P<0.05).2.Compared with no metabolic syndrome patients,the risk of early-onset stroke in metabolic syndrome patients is significantly increased by 1.52 times(OR:2.52,95%CI:1.51-4.19).Components of metabolic syndrome such as overweight and/or obesity(OR:1.94,95%CI:1.21-3.09),hyperglycemia(OR:1.67,95%CI:1.00-2.08)and dyslipidemia(OR:1.67,95%CI:1.04-2.69)are significantly associated with the increased risk of early-onset stroke.3.Referred to those normal homocysteine,multivariate-adjusted odds ratios for early-onset stroke among participants with hyperhomocysteinemia was 1.89(95%CI:1.05-3.41),the adjusted odds ratio was 1.57(95%CI:1.03-2.38)for every 10.41?mol/L increase of homocysteine.4.Compared with those without overall healthy lifestyle,the risk of early-onset stroke in the overall healthy lifestyle was significantly reduced by 59%(OR:0.41,95%CI:0.19-0.91).In addition,the risk of early-onset stroke in normal BMI patients was significantly reduced by 42%(OR:0.58,95%CI:0.36-0.93),compared with those with overweight or obesity.Conclusions:In stroke patients,metabolic syndrome,the related metabolic disorders(overweight and/or obesity,hyperglycemia and dyslipidemia)and hyperhomocysteinemia was significantly associated with higher risk of early-onset stroke,but the overall healthy lifestyle and normal BMI would reduce the risk of early-onset stroke.