Effect Of Shufeng Jiedu Capsule On "Phlegm-heat Blocking Lung" Type AECOPD(GradeⅠ And Grade Ⅱ)

ObjectiveTo observe the curative effect of Shufeng jiedu capsule combined with conventional AECOPD treatment regimen on grade I and grade II clinical manifestations of acute exacerbation of chronic obstructive pulmonary disease of "phlegm heat obstruction of lung" type.Methods200 patients who met the inclusion criteria of "phlegm heat obstruction lung" type AECOPD were randomly divided into experimental group and control group,and 100 cases were observed in each group.Control group: routine AECOPD treatment regimen(oxygen inhalation,anti-infection,cough,phlegm,bronchodilator use,etc.).Experimental group: on the basis of routine AECOPD treatment plan plus Shufeng jiedu capsule,7 days as the observation course.The clinical efficacy,TCM syndrome score,clinical pulmonary infection score(CPIS),arterial blood gas(Pa02 、 Pa CO2),serum amyloid A(Seruma)were compared between the two groups Results(1)Clinical efficacy: the total effective rate of the experimentalgroup was 87%,the total effective rate of the control group was 75%,and the total effective rate of the two groups was statistically different(P<0.05),suggesting that the overall effective rate of the experimental group was better than that of the control group.(2)TCM symptom score :1 total score: the scores of TCM symptoms in the experimental group and the control group decreased after treatment,and the experimental group was better than the control group(P<0.05);2 individual scores: cough,wheezing,phlegm,fever,phlegm,thirst,dry stool,wheezing scores decreased after treatment in the experimental group and control group(P<0.05).(3)Clinical pulmonary infection score(CPIS): the scores of the experimental group and the control group after treatment were lower than those before treatment(P<0.01),and the experimental group was better than the control group(0.05).(4)Blood gas analysis :1 Pa O2(mmhg): the Pa O2 of the experimental group and the control group improved after treatment(P>0.05);but there was no difference between the two groups(P>0.05);2Pa CO2(mmhg),the Pa CO2 of the experimental group and the control group decreased after treatment(0.05);and the improvement of theexperimental group was better than that of the control group(P<0.05).(5)Inflammatory factors: the serum SAA、IL-6、PCT、CRP levels of the experimental group and the control group were lower than those before treatment(P<0.05),and the experimental group was lower than that of the control group(P<0.05).(6)Average hospitalization days comparison: the average hospitalization days of the experimental group were shorter than the average hospitalization days of the control group(P<0.05).(7)Intubation rate comparison: the intubation rate during hospitalization was 11% in the experimental group and 10% in the control group,and there was no difference between the groups(P>0.05).(8)Pulmonary function comparison: the lung function of the experimental group and the control group was better than that before treatment(P<0.05),and there was no difference between the two groups(P<0.05).Conclusion:1.Shufeng jiedu capsule combined with conventional AECOPD treatment regimen for "phlegm-heat obstruction of lung" typeAECOPD compared with conventional treatment regimen,can better improve the patient’s clinical symptoms,signs and serum SAA,IL-6,PCT,CRP levels,better inhibition of inflammatory response.2.Shufeng jiedu capsule combined with routine AECOPD treatment regimen can shorten the average hospitalization days.