The Effect Of Intraoperative Autotransfusion On Inflammatory Cells And Coagulation In Patients With Meningiomas

Objective:Meningioma is one of the most common primary intracranial tumors.Surgical resection is the main treatment of meningioma,but because of the abundant blood supply of meningioma and the large amount of intraoperative hemorrhage,blood transfusion is often needed to ensure the safety of patients.Allogeneic blood transfusion can increase the risk of tumor recurrence,postoperative infection and acute lung injury.Autotransfusion is widely used in bone surgery,gynecology and other operations.However,in neurosurgery,the research of autotransfusion is mostly concentrated in subarachnoid hemorrhage,brain injury and spinal surgery.The research of auto transfusion in meningioma surgery is still in progress of further enrichment.We will review the clinical data of related patients,analyze the safety of autotransfusion in meningioma operation,and its effect on prognosis,inflammatory cells and coagulation functionMethods:The clinical data of 64 patients with meningioma from January 2014 to June 2019 in the third Department of Neurology,Qianfoshan Hospital Affiliated to Shandong University were analyzed retrospectively.According to whether intraoperative autotransfusion technology was used during the operation,the patients were divided into autotransfusion group and non-autotransfusion group.The safety of auto transfusion was determined according to the postoperative complications and long-term follow-up.Correlation analysis was used to compare the length of stay in hospital,the time of antibiotic application,the blood routine and coagulation function indexes of 1 day and 7 days after operation in the two groups,so as to determine whether the application of intraoperative washing autotransfusion technology in meningioma surgery has an impact on the prognosis,inflammatory cells and coagulation function of patientsResults:1.In the non-autotransfusion group,there was 1 patient with transfusion-related non-hemolytic fever.There were no obvious adverse reactions such as fever and allergy in autotransfusion group.Up to now,among the 64 patients involved in this study,there was one case of meningioma recurrence in situ in both groups,and no distant metastasis of the tumor occurred in all patients.2.There was no significant difference between the two groups in hospital days and antibiotic application time.One day after operation,the number of leukocytes and the percentage of neutrophils in autotransfusion group were higher than those in non-autotransfusion group,while the percentage of lymphocytes in autotransfusion group was lower than those in non-autotransfusion group,but there was no significant difference in the above indexes between the two groups 7 days after operation.There was no significant difference in other blood cell classification indexes and coagulation function indexes between the two groups before operation,1 day after operation and 7 days after operation.Conclusion:1.There is no significant relationship between intraoperative washing autotransfusion and recurrence or metastasis after meningioma resection,and it does not increase blood transfusion related complications such as fever reaction,hemolysis reaction,hospital stay and antibiotic application time in patients undergoing meningioma resection.2.The number of leukocytes and the proportion of neutrophils in the patients with washing autotransfusion during the operation will increase in a short period of time,and the number of lymphocytes will decrease in a short period of time,but the change will recover within one week.3.There was no significant difference in the counts of red blood cells,platelets and coagulation function between the patients who used the intraoperative autotransfusion technique and those who did not.