Comparative Study Of Blood Component Transfusion And Whole Blood Transfusion In Obstetric Patients With Pre-Disseminated Intravascular Coagulation

Objects:To study the efficacy of Blood component transfusion in obstetric patients with the aura of disseminated intravascular coagulation, and make clear that Blood component transfusion is of much important in obstetric patients with the aura 0f disseminated intravascular coagulation. Methods:Select the 78 obstetric patients with the aura of Disseminated intravascular coagulation, which be treated from Puyang hospital during March 2013 to Septemer 2015, age 22~36, mean age 27.8±4.1, Primipara 42 cases, Multipara 36 cases, Gestational weeks 34~40 weeks, mean time 37.3±2.5 weeks. All the cases have Symptoms of Flustered, limb cold and wet, decreased blood pressure,Vaginal bleeding and other performance, with or without subcutaneous congestion,the estimated blood loss is 780~1500ml. Causes of DIC: Abruption 16 cases(20.51%), 27 cases of severe preeclampsia(34.62%), 13 cases of placenta previa(16.67%), amniotic fluid embolism 4 cases(5.13%), 18 cases of uterine inertia(23.08%). All patients were randomly divided into study group(n = 39 patients) and control group(n = 39 patients) In the study group, the blood was infused and the control group was infused with blood based on random number table method;In the study group, the Component blood was infused and the control group was infused with whole blood. APTT(Full spell activated partial thromboplastin time),TT(Full spell thrombin time), PT(Full spell prothrombin time) and FGB(Also known as fibrinogen) and RBC(Full spell red blood cell), HGB(Full spell hemoglobin), HCT(Full spell hematocrit) and PLT(Full spell platelets), such as blood and other coagulation changes some adverse reaction were recorded and compared before and after transfusion hemoglobin,Such as allergic reaction, non hemolytic febrile reaction, low temperature reaction, hemolytic reaction, congestive heart failure and pulmonary edema, etc. Results:we can draw the following results, after clinical intervention therapy:(1)Before blood transfusion, postnatal day 1, postnatal day 3, two groups' patients HR, DBP, SBP, MAP were no statistically significant; after suffering a blood transfusion, SBP, MAP of two groups statistically significant(P <0.05).(2)39 patients in the study group, mean red blood cell transfusion suspension(13.8 ± 4.2)U, FFP(837.1 ± 107.5) mL, cryoprecipitate infusion of 22 cases, the average infusion(12.3 ± 3.5) U, 20 U supplement platelets were 18 cases. 79 cases in the control group, the average whole blood(1526 ± 178.2) mL.(3)After blood transfusion, two groups' patients, APTT(Full spell activated partial thromboplastin time), TT(Full spell thrombin time), PT(Full spell prothrombin time) and FGB(Also known as fibrinogen) and RBC( red blood cell), HGB( hemoglobin), HCT( hematocrit) and PLT( platelets), such as blood and other coagulation parameters were significantly improved before transfusion, the difference was statistically significant(P <0.05).(4)Study group's clotting time, prothrombin time, and platelet contentwere significantly better than the control group, and the difference has statistically significant(P <0.05). Conclusion:FGB(also knows as Fibrinogen), APTT( full spell activated partial thromboplastin time),HGB(full spell Hemoglobin), red blood cell(RBC) and hematocrit(HCT),and are equivalent between two groups, but the platelet(PLT), coagulation prothrombin time(PT), thrombin time(TT) and other indicators of the study group are significant better than the control group, and hemostasis in patients with good clinical outcome, serious adverse transfusion reactions did not occur, showing relatively transfusion of whole blood component transfusion treatment of postpartum hemorrhage threatened and DIC has significant advantages.