Clinical Value Of The Monocyte To High Density Lipoprotein Cholesterol Ratio In Patients With Coronary Atherosclerotic Disease And Type 2 Diabete Mellitus

Background and Objective:Objective:In this study,we analyzed the differences between monocyte counts,high-density lipoprotein cholesterol(MHR),CRP,and HbA1c and their correlation with coronary SYNTAX scores in patients with coronary atherosclerotic disease(CAD)and type 2 diabetes mellitus(T2DM)to provide experimental evidence for clinical diagnosis and treatment of the disease.Methods:292 patients who underwent coronary angiography(CAG)at the Department of Cardiology of Zhengzhou People's Hospital affiliated to Southern Medical University from April 2018 to April 2019 were grouped 3 groups,according to the results of CAG and whether they had T2DM.control group(n=90):without CAD or T2DM;CAD group(n=106):with CAD but no T2DM.CAD and T2DM group(n=96):with CAD and T2DM.We compared the clinical data,SYNTAX,HbA1c,CRP and MHR among the three groups and tried to find their relationship.Besides,SYNTAX score(SS)was used to assess CAG results,according to SS,the CAD group and the group with CAD and T2DM were regroup(n=202):low-risk group:SS?22,high-risk group:SS>22.We compared the clinical data,SYNTAX,HbAlc,CRP and MHR between the two groupsResults:(1)? Compared with the control group and the CAD group,there was not statistically different in gender,age,height,BMI,smoking history,hypertension,history of hyperlipidemia,Cr,UA,BUN,RBC,PLT,TG,TC,LDL-C,apoA1,apoB,Lp(a),HbA1c,but statistically significant in weight,HDL-C,CRP,TnI,and MHR(P<0.05).?Compared with the control group and the group with CAD and T2DM,there was not statistically different in gender,age,height,smoking history,history of hypertension,history of hyperlipidemia,Cr,UA,BUN,RBC,PLT,TC,LDL-C,apoA1,apoB,Lp(a),but statistically significant in weight,HbAlc,BMI,TG,Monocyte,HDL-C,CRP,TnI,and MHR(P<0.05).?Compared with the CADgroup and the group with CAD and T2DM,there was not statistically different in gender,age,height,smoking history,history of hypertension,history of hyperlipidemia,Cr,UA,BUN,RBC,PLT,TC,LDL-C,apoA1,apoB,Lp(a),but statistically significant in weight.HbAlc,BMI,TG,Monocyte,HDL-C,CRP,TnI,and MHR,SS(P<0.05).(2)MHR had positive correlations with SYNTAX,HbA1c,CRP,(r=4.53?0.66?0.75,P<0.05).(3)Compared with the low-risk group and the high-risk group,there was not statistically different in gender,age,height,smoking history,history of hypertension,history of hyperlipidemia,Cr,UA,BUN,RBC,PLT,TG,TC,LDL-C,apoA1,apoB,Lp(a),but statistically significant in weight,HbAlc,BMI,Monocyte,HDL-C,CRP,TnI,and MHR,SS(P<0.05).Conclusion:The serum MHR in CAD and T2DM was significantly higher than CAD or control group.The serum MHR values in patients with CAD and T2DM are positively correlated with their HbAlc and hs-CRP levels.Suggesting that the severity of diabetes and inflammatory response are closely related to the increase of MHR.The degree of coronary stenosis(according to SS)was higher in patients with CAD and T2DM than in patients with coronary heart disease alone,and the MHR value in patients with CAD and T2DM was positively correlated with the degree of coronary stenosis,suggesting that MHR value may be used to assess the degree of coronary artery stenosis in patients with coronary heart disease and diabetes as a simple clinical indicators.