To Evaluation The Clinical Effect Of Different Drug Management After Ovarian Endometriosis Cyst Surgery

ObjectiveTo investigate the clinical effect of different drug management after ovarian endometriosis cyst surgery.To provide a theoretical reference for the choice of drug treatment regimen for EMT patients in clinic.Methods120 cases of ovarian endometriosis cyst patients undergoing laparoscopic surgery in our hospital from September 2015 to May 2017 were selected.The age of the patients ranged from 20 to 38 years,with an average of(31.4±5.94)years.Patients were divided into three groups according to different treatment regimens.Group A:GnRHa treatment group;group B:Yousiming treatment group;group C:GnRHa combined with Yousmin treatment group.All patients were followed up for 2 year.The therapeutic efficacies,adverse reaction rate,recurrent rates,ovulation rates,ovarian function index,menstrual recovery time,alleviation rate of dysmenorrhea,serum CA125 levels at different time points in the three groups were analyzed.Results1.After treatment,the levels of FSH,LH,E2 and AMH in the three groups were significantly lower than those of before operation(P<0.05),After treatment,the levels of FSH,LH,E2 in group B and group C were significantly lower than those of in group A(P<0.05),the levels of AMH in group B and group C was significantly higher than that of in group A(P<0.05).After treatment,the levels of FSH,LH,E2 in group C were significantly lower than those of in group B(P<0.05),the levels of AMH in group C was significantly higher than that of in group B(P<0.05).2.The levels of CA125 after laparoscopic surgery in the three groups was significantly lower than those of before operation(P<0.05).CA125 level in group B and group C was significantly lower than that of in group B 24 months after operation(P<0.05).3.The improvement rates of symptoms in group B and group C was significantly higher than that of in group C 24 months after operation(P<0.05).The improvement rates of symptoms in group C was significantly higher than that of in group B 24 months after operation(P<0.05).4.The recurrence rates of group B and group C was significantly lower than that of group A at 12,18 and 24 months after operation(P<0.05),and the recurrence rates of group C was significantly lower than that of group B at 18 and 24 months after operation(P<0.05).5.The ovulation rate of group B and group C at 24 months after operation was significantly higher than that of group A(P<0.05),and the ovulation rate of group C at 24 months after operation was significantly higher than that of group B(P<0.05).The remission rate of dysmenorrhea in group B and group C was significantly higher than that of in group A(P<0.05),and the remission rate of dysmenorrhea in group C was significantly higher than that of in group B(P<0.05).6.The incidence of adverse reactions in group A was significantly higher than that of in group B and group C(P<0.05).There was no significant difference in the incidence of adverse reactions and menstrual recovery time between group B and group C(P>0.05).There was no significant difference in the menstrual recovery time comparison of group A,group B and group C(P>0.05).ConclusionsGnRHa combined with Yousiming treatment in ovarian endometriomas can significantly improve the clinical outcome and the rate of ovulation,reduce the rate of recurrence and promote the recovery of ovarian function.This medication regimen is safe and effective for patients with ovarian endometriosis cyst undergoing laparoscopic surgery.