Analysis Of Correlative Risk Factors Of Diabetic Kidney Disease With Type 2 Diabetic Mellitus

BackgroundType 2 Diabetes Mellitus has become a common disease and frequently-occurring disease in today's world,along with our country economy development is rapid,the change of dietary structure,the decline of physical activity,population aging and other factors,the incidence of diabetes mellitus has the world's first in China,at the same time,it is frightening that about 60% of the patients are still not clinically diagnosed in our country,and most patients with confirmed the blood glucose control are not ideal,longterm hyperglycemia can cause damage to blood vessels,nerves,etc..Among them,Diabetic kidney disease is one of the more common chronic microvascular complications that seriously affects patients' quality of life.With the disease progression,kidney function gradually deteriorates to dialysis,currently,DKD has become an important cause of end-stage kidney disease and even death.There are many factors that affect the progression of DKD,such as blood glucose,blood pressure,blood lipid,duration,age,obesity,bad living habits and etc.,these factors may have important effects on causing and accelerating the progress of DKD,this study analyzed the related risk factors of DKD in patients with T2 DM,and provided early intervention for patients with T2 DM to delay the occurrence and development of DKD.ObjectiveThe related risk factors of type 2 diabetic kidney disease were discussed,it provides effective evidence for early clinical intervention and treatment,and delaying the progress of DKD.MethodsUsing questionnaire to collect 658 patients with T2 DM who were admitted to the Endocrinology Department of our hospital from January 2018 to June 2019,among them,139 patients were excluded because of repeated hospitalizations,lack of relevant research indicators,end-stage kidney disease dialysis patients and kidney damage caused by other diseases,and a total of 519 patients were finally included in this study.Groups were divided according to the 24-hour Urine micro albumin(Um Alb),Um Alb <30mg/24 h was the simple T2 DM group,Um Alb ?30mg/24 h or serum creatinine exceeding the upper limit of normal was the DKD group,and the normal reference value of serum creatinine was 49-97umol/L.The content of the questionnaire includes the general condition of patients,gender,age,course of disease,body mass index,systolic blood pressure,diastolic blood pressure,history of smoking,history of drinking,family history of diabetes,history of hypertension,record laboratory parameters including fasting blood glucose,2 hours postprandial blood glucose,glycosylated Hemoglobin,24-hour urine micro albumin,serum creatinine,serum uric acid,blood lipids,etc..The questionnaire was recorded by the researcher himself.All data were statistically analyzed using SPSS 24.0 statistical software.Count data were expressed as rate or constituent ratio,Chi-square test was used for comparison between groups,The measurement data that conforming to the normal distribution were expressed by mean±standard deviation,for homogeneity of variance,the groups of data were comparison using t test.The measurement data that do not meet the normal distribution were expressed by median(interquartile range),and the comparison between groups with uneven variance was used Non-parametric test.The influencing factors of DKD were analyzed by binary logistic regression.P<0.05 indicates statistical significance.Results1.Among 519 hospitalized patients with T2 DM,257 were Diabetic kidney disease,with a prevalence of 49.5%,among them,164 males,accounting for 63.8%,93 females,accounting for 36.2%.2.There were statistically significant differences in gender,age,systolic blood pressure,diastolic blood pressure,history of smoking,history of drinking,history of hypertension,fasting blood glucose,glycosylated hemoglobin,serum uric acid,high density lipoprotein,total cholesterol in the simple T2 DM group and DKD group(P<0.05).course of disease,Body mass index,2 hours postprandial blood glucose,family history of diabetes,triglyceride,low density lipoprotein were not significant differences between the two groups(P>0.05).3.Logistic regression analysis found that systolic blood pressure,glycosylated hemoglobin,serum uric acid,history of smoking,and total cholesterol were positively related to DKD,which were risk factors,high density lipoprotein was negatively related to DKD,which were protective factors.Conclusion1.The prevalence of DKD is high in hospitalized patients with T2 DM.2.Gender,age,systolic blood pressure,diastolic blood pressure,history of smoking,history of drinking,history of hypertension,fasting blood glucose,glycosylated hemoglobin,serum uric acid,high density lipoprotein,total cholesterol are related to the occurrence of DKD.3.Glycosylated hemoglobin,systolic blood pressure,serum uric acid,history of smoking,total cholesterol may be risk factors for DKD,high density lipoprotein may be protective factor for DKD.