| Research Background:Chronic kidney disease has the characteristics of high incidence,high mortality.Studies have shown that the prevalence of CKD in China's adult population is 10.8%.With the increasing incidence of diabetes,hypertension,and gout,more and more people get the disease.Especially in the end-stage renal disease,it is easy to combine multiple complications,which has a greater impact on the quality of life of patients with CKD,and the treatment methods are limited.It has a heavy economic burden on the world.Currently common treatments include hemodialysis and peritoneal dialysis.For affordable patients,kidney transplantation can be considered.Previous animal experiments have confirmed that the Tongfu Xiezhuo method can regulate the intestinal flora of rats with chronic kidney disease,reduce the production of intestinal endotoxin,improve the inflammatory state,and delay the progress of renal function.Purpose:Based on the theory of "gut kidney axis",this paper discusses the mechanism of Tongfu Xiezhou method in the treatment of chronic kidney disease,delaying the progress of renal function,alleviating systemic micro inflammatory reaction,regulating intestinal barrier function and so on,so as to better guide clinical medication,highlight the characteristics of traditional Chinese Medicine,and provide research basis for the effective treatment of CKD by traditional Chinese medicineMethods:The 88 CKD patients eligible for enrollment were divided into control group and treatment group according to the principle of random allocation.All patients were treated with basic Western medicine to maintain electrolyte balance.The treatment group was treated with traditional Chinese medicine low-level retention enema.Each treatment was reserved for 30 minutes,3 times a week,4 weeks were used as a course of treatment.The operation was performed according to standard rules.At the same time,the control group was treat with Niaoduqing particles,3 times a day,4 weeks were used as a course of treatment.Record the TCM syndrome scores,inflammation index(CRP),renal function(Scr,BUN,CysC,UA),intestinal mucosal barrier function(D-lactic acid,endotoxin,DAO)changes both before and after treatment comparison of relevant indicators before and after treatment.Using SPSS24.0 statistical software and related professional knowledge to analyze the test results and draw conclusions.Result:(1)Comparie the TCM Syndrome Symptom Points:The results showed that there was a statistically significant difference in the total scores between the two groups of patients after treatment(P<0.01),and the difference in scores before and after treatment in the treatment group was significantly higher than that in the control group(P<0.05).(2)Compare the clinical efficacy:40 cases in the treatment group,total effective rate 95.00%;38 cases in the control group,total effective rate was 84.21%.The chi-square test showed that the treatment group's total effective rate higher than that the control group(P<0.05).(3)Compare the renal function:The results showed that SCR and BUN in the treatment group were significantly lower than those in the control group(P<0.05),and there was no significant difference between the treatment group and the control group(P>0.05).There were significant differences in SCR,bun and before and after treatment in the treatment group(P<0.05)and before and after treatment in the control group(P<0.05),but there were no significant differences in bun,UA and CysC before and after treatment(P>0.05).(4)Comparing the eGFR of the two groups before and after treatment:the results showed that there was no significant difference between the two groups after treatment(P>0.05),but there was significant difference between the two groups before and after treatment(P<0.05),and the difference between the two groups before and after treatment was significantly higher than that of the control group(P<0.05).(5)C-reactive protein(CRP):the results showed that there was no significant difference between the treatment group and the control group(P>0.05).(6)Compare the intestinal mucosal barrier function indexes before and after treatment in the two groups:The results showed that D-lactate and endotoxin in the treatment group were significantly lower than those in the control group(P<0.05).There was no significant difference in Dao between the two groups after treatment(P=0.830>0.05),but Dao in the treatment group decreased more significantly than that in the control group.Conclusion:The threapy of TongFu Xiezhuo can improve the symptoms of TCM in patients with stage CKD3-4,reduce the level of uremic toxins,increase the glomerular filtration rate,and delay the progress of renal function.At the same time,it was found that the TongFu Xiezhuo method can reduce micro-inflammatory reactions,improve the intestinal mucosal barrier function,and provide clinical evidence for further promotion and use. |
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