Effect Of Yiqi Tongfu Zhuyu Decoction Enema Therapy On The Intestinal Mucosal Barrier Function In Patients With Sepsis

Objective:To study Yiqi Tongfu Zhuyu decoction enema therapy for treatment of patients with sepsis and its possible mechanism.Methods:In accordance with sepsis diagnostic criteria, select 40 cases of septic patients, using random number table, randomly divided into two groups.On The basis of Western medicine treatment of two groups,the treatment group with Yiqi Tongfu Zhuyu decoction enema therapy, the control group with normal saline enema therapy, both 2 times a day,7 days a course of treatment, observation period of 14 days.In two groups before and after treatment to all patients TCM syndrome score, APACHE II score,as calculated and compared between two groups of treatment efficiency. Test their blood of D-lactic acid, urinary lactulose/mannitol (L/M) values,then compare them when treatment started, after treated 3days,7days,14days,for each index changes.Also compare acute respiratory distress syndrome, multiple organ dysfunction syndrome incidence and mortality in 28 days of two groups.Results:Before treatment TCM syndrome score and APACHEâ…¡score of two groups were no significant difference (p>0.05), similar severity of the disease. The two groups after treatment decreased TCM syndrome score (p<0.05), the treatment group than in the control group decreased more significantly (p<0.05). Treatment group's complete recover and effective rate was 35.3%, the complete recover and effective rate in the control group was 5.6%.Their difference was significantly statistical (p<0.05). Treatment group after 7 days and 14 days, compared with the control group D-lactate levels, Their difference was significantly statistical difference (p<0.05); therapy after 14d than the control group, urinary L/M level has significantly statistical difference (p<0.05);After treatment, acute respiratory distress syndrome and multiple organ dysfunction syndrome incidence of the treatment group have statistically significant differences with the control group (p<0.05); mortality in 28 days of two groups have no statistically significant differences (p>0.05).Conclusion:Yiqi Tongfu Zhuyu decoction enema therapy can significantly improve the symptoms of septic patients,improve their clinical treatment efficiency,reduce the clinical acute respiratory distress syndrome and multiple organ dysfunction syndrome incidence. The mechanism may be related to protection of intestinal mucosa barrier function and prevention of bacterial endotoxin translocation relevant.