Effect Of Yishenjianpi Decoction On Anovulatory Infertility Caused By PCOS With Deficiency Of Spleen And Kidney

Objective:The purpose of this study is to observe the menstrual status,TCM syndrome score of Spleen-Kidney Deficiency syndrome,serum sex hormone level,AMH level,endometrial thickness,change of basal body temperature curve,ovulation rate and pregnancy rate of patients with ovulation disorder infertility caused by polycystic ovary syndrome(PCOS)with deficiency of spleen and kidney treated by the addition and subtraction of Yishenjianpi formula and evaluate the clinical efficacy of Chinese medicine in treating ovulatory dysfunction infertility caused by PCOS,so as to provide new effective methods and clinical ideas for improving pregnancy rate and clinical symptoms of PCOS women in childbearing ageMethods:60 cases of anovulation infertility of PCOS with deficiency of spleen and kidney are randomly divided into two groups:the control group is given letrozole orally,the treatment group is given the addition and subtraction of Yishenjianpi formula based on the control group,a total of 3 menstrual cycles.To observe the improvement of menstruation,the change of TCM syndrome score,serum sex hormone level,AMH level,the change of basic temperature curve and the change of endometrial thickness before and after treatment in the two groups,also record the endometrial thickness of patients in both groups during the treatment,and count the ovulation rate and pregnancy rate of the two groups,then finally carry out statistical analysis to evaluate the therapeutic effect of the treatment of PCOS with deficiency of spleen and kidney inducing infertility by the addition and subtraction of Yishenjianpi formula.Result:(1)Before treatment,there is no significant statistical difference in age,infertility years,TCM syndrome score,menstrual score,serum sex hormone level and AMH level between the two groups,which is comparable;(2)Menstrual score comparison:after treatment,there is no significant difference of menstrual score in control group.The menstrual score of the treatment group decreased before and after treatment,and there is significant difference between the two groups(P<0.05);(3)TCM syndrome score comparison:after treatment,TCM syndrome score of the two groups decreased,but the decrease of the treatment group is significantly greater than that of the control group,there is significant difference between the two groups.The treatment group is better than the control group in improving the symptoms of spleen and kidney deficiency(P<0.05);(4)Comparison of serum sex hormone level:after treatment,there is no significant difference in control group in serum sex hormone level before and after treatment(P>0.05),there is no significant difference in serum E2,FSH and PRL level after treatment in the treatment group compared with before treatment(P>0.05),serum LH and T levels decreased significantly compared with before treatment,and the difference is significantly better than that in the control group(P<0.05);(5)AMH level comparison:before and after treatment,AMH level of the two groups decreased,but the decrease of the treatment group is significantly better than that of the control group,there is a significant difference between the two groups(P<0.05);(6)Comparison of basic body temperature:after treatment,the biphasic rate of basic body temperature in the treatment group is higher than that in the control group(P<0.05);(7)Rate of ovulation:The ovulation rate is 65%in the treatment group and 40%in the control group(P<0.05);(8)Comparison of endometrial thickness:During the treatment,endometrial thickness in the treatment group is significantly higher than that in the control group,the difference is significant(P<0.05);That is,the endometrial thickness of patients in the treatment group is better than that of patients in the control group.(9)Pregnancy rate comparison:after treatment,the pregnancy rate of the treatment group is 26.66%,and that of the control group is 13.33%,there is no significant difference(P>0.05);(10)Overall efficacy comparison:after treatment,the total clinical effective rate of the treatment group is 83.33%,and the effective rate of the control group is 56.67%.The therapeutic effect of the treatment group is better than that of the control group,with a significant difference(P<0.05).Conclusion:the treatment of Yishenjianpi formula can effectively improve the menstruation and hormone level of patients with anovulatory infertility caused by PCOS with deficiency of spleen and kidney,relieve the clinical symptoms of patients,promote the development and expulsion of follicles,and improve the pregnancy rate.It has definite effect and high safety.