Study On The Relationship Between TSH Levels And Ovarian Reserve Function In Patients With Polycystic Ovary Syndrome

Objective:Studies showed that polycystic ovary syndrome and thyroid dysfunction may have interactions.However,There is rare research to analyze the effects of thyroid function on ovarian function in patients with PCOS.The study intended to analyze the relationship between elevated thyroid-stimulating hormone(TSH)level and Anti-Mullerian Hormone(AMH)level,Antral Follicle Count(AFC)to determine the effect of thyroid-stimulating hormone on ovarian reserve.Methods:The study population was diagnosed with polycystic ovary syndrome with normal thyroid function from January 2016 to December 2018 at the Center for Reproductive Medicine,Affiliated Hospital of Jining Medical University.The following indicators were collected:age,anti-Müllerian hormone,body mass index,Thyroid stimulating hormone,triiodotyronine,tetraiodotyronine,infertility duration,follicle-stimulating hormone,luteinizing hormone,LH/FSH ratio,testosterone,antral follicle count,type of infertility.The study population was grouped according to BMI,BMI<25kg/m~2 was the non-obese group,and BMI≥25kg/m~2 was the obese group.Univariate analysis model was used to analyze the associations between TSH levels with AMH levels,AFC and other variables.Then,after adjusting these potential factors,we further applied a multiple regression model to test whether TSH level and AMH level,AFC were independently related,respectively.Results:In the non-obese group,there was no significant relationship between TSH levels and AMH levels and AFC;In the obese group,TSH levels were negatively related with AMH levels after adjusting related variables(β=-0.97,P=0.0079);however,there was no significant relationship between TSH level and AFC in the obesity group.Conclusion:TSH levels have a significant negative relationship with AMH levels in patients with PCOS with normal thyroid function whose BMI≥25kg/m~2.Therefore,weight loss may bring benefits to the ovarian reserve in patients with polycystic ovary syndrome.