Study On The Relationship Between TCM Syndrome Types Of Type 2 Diabetic Peripheral Neuritis And CRP,SAA And Other Indexes

Purpose:Through the collection of clinical data,to explore the correlation between TCM syndrome types of type 2 diabetic peripheral neuritis and hypersensitive C-reactive protein(hs-CRP),Serum amyloid A(SAA),hemorheology and blood lipids,so as to develop new ideas for the prevention and treatment of type 2 diabetic peripheral neuritis with traditional Chinese and western medicine.Method:Two hundred patients with type 2 diabetic peripheral neuritis were collected from the Department of Endocrinology of Yunnan Provincial Hospital of traditional Chinese Medicine and the Department of traditional Chinese Medicine of Yunnan second people's Hospital from January 2019 to January 2020,which belonged to five syndrome types:damp-heat blocking collaterals syndrome,qi deficiency and blood stasis syndrome,yin deficiency and blood stasis syndrome,phlegm and blood stasis syndrome and liver and kidney deficiency syndrome.The course of diabetes,hs-CRP,SAA,hemorheology,blood lipid and other indexes were recorded.After a comprehensive review of the data,SPSS26.0was used to analyze the correlation.Result:1.Distribution of TCM syndrome types: Qi deficiency and blood stasis syndrome(24.5%)> liver and kidney deficiency syndrome(22.5%)> Yin deficiency and blood stasis syndrome(19.5%)> damp-heat blocking collateral syndrome(19.0%)> phlegm and blood stasis blocking collaterals syndrome(14.5%).2.There was a correlation between TCM syndrome type and the course of diabetes mellitus(P=0.00).After multiple comparison,the course of diabetes mellitus of qi deficiency and blood stasis syndrome(P=0.038),yin deficiency and blood stasis syndrome(P=0.022),phlegm and blood stasis syndrome(P=0.003)and liver and kidney deficiency syndrome(P= 0.00)was longer than that of damp-heat syndrome,and the course of diabetes of qi deficiency and blood stasis syndrome(P= 0.006)and yin deficiency and blood stasis syndrome(P=0.023)was shorter than that of liver and kidney deficiency syndrome,and the difference was statistically significant.The course of diabetes shows an increasing trend among syndrome types: damp-heat blocking collaterals syndrome < qi deficiency and blood stasis syndrome < yin deficiency and blood stasis syndrome <phlegm and blood stasis syndrome < liver and kidney deficiency syndrome.3.There is a correlation between TCM syndrome type and hs-CRP(P=0.001).After multiple comparison,the hs-CRP level of qi deficiency(P=0.037)and blood stasis syndrome and dampness-heat blocking collaterals syndrome(P=0.01)is lower than that of liver and kidney deficiency syndrome,and the difference is statistically significant.There was no significant correlation between TCM syndrome type and SAA(P=0.69).The TCM syndrome type was correlated with the level of TC(P=0.047)and LDL-C(P=0.00).There was no significant correlation between the TCM syndrome type and the level of TG(P=0.986)and HDL-C(P=0.426).The overall average level of TC and TG was slightly higher than the normal reference range.After multiple comparisons,the TC levels of liver and kidney deficiency syndrome(P=0.002 and qi deficiency and blood stasis syndrome(P=0.035)were higher than those of damp-heat blocking collaterals syndrome.The LDL-C levels of Yin deficiency and blood stasis syndrome(P=0.009)and damp-heat syndrome(P=0.003)were significantly lower than those of phlegm and blood stasis syndrome,while the LDL-C levels of damp-heat syndrome(P=0.00),qi deficiency and blood stasis syndrome(P=0.001)and yin deficiency and blood stasis syndrome(P=0.00)were significantly lower than those of liver and kidney deficiency syndrome.4.The TCM syndrome type was correlated with whole blood viscosity 1(P=0.00),whole blood viscosity 150(P=0.002),whole blood viscosity 200(P=0.039)and erythrocyte aggregation index(P=0.025).After multiple comparisons,the whole blood viscosity 1 level of damp-heat blocking collaterals syndrome(P=0.001),qi deficiency and blood stasis syndrome(P=0.003)and yin deficiency and blood stasis syndrome(P=0.004)were significantly lower than those of liver and kidney deficiency syndrome,while the whole blood viscosity 150 levels of damp-heat collateral obstruction syndrome(P=0.001),qi deficiency and blood stasis syndrome(P=0.000),yin deficiency and blood stasis syndrome(P=0.001),phlegm and blood stasis syndrome(P=0.04)were lower than those of liver and kidney deficiency syndrome,and the whole blood viscosity levels of damp-heat collateral obstruction syndrome,qi deficiency and blood stasis syndrome,yin deficiency and blood stasis syndrome,phlegm and blood stasis syndrome were significantly lower than those of liver and kidney deficiency syndrome.The whole blood viscosity 200 level of qi deficiency and blood stasis syndrome(P=0.007),damp-heat syndrome(P=0.007)and yin deficiency and blood stasis syndrome(P=0.032)were lower than those of liver and kidney deficiency syndrome,and the erythrocyte aggregation index levels of damp-heat syndrome(P=0.003),qi deficiency and blood stasis syndrome(P=0.016),yin deficiency and blood stasis syndrome(P=0.018)and phlegm and blood stasis syndrome P=0.026)were significantly lower than those of liver and kidney deficiency syndrome.There was no significant correlation between TCM syndrome type and plasma viscosity,hematocrit,platelet aggregation rate,erythrocyte deformation index(tk)and erythrocyte sedimentation rate(P>0.05).5.Taking five syndrome types as dependent variables,and taking the course of diabetes,hs-CRP,TC,LDL-C,whole blood viscosity 1,whole blood viscosity 150,whole blood viscosity 200,erythrocyte aggregation index and other correlation indexes as independent variables,the syndrome of damp-heat blocking collaterals was negatively correlated with TC,LDL-C and the course of diabetes,while the syndrome of qi deficiency and blood stasis was positively correlated with TC.Yin deficiency and blood stasis syndrome was positively correlated with whole blood viscosity 200,but negatively correlated with LDL-C and whole blood viscosity 1;phlegm and blood stasis blocking collaterals was not significantly correlated with each index;liver and kidney deficiency syndrome was positively correlated with LDL-C,whole blood viscosity 1 and erythrocyte aggregation index.Conclusion:1.In the early health education of diabetes,prevention should be emphasized to avoid too early and overweight complications in the process of diabetes.2.The results of this study found that there is a certain correlation between TCM syndrome type of type 2 diabetic peripheral neuritis and the course of diabetes,hs-CRP,blood lipids,hemorheology and other indicators,these correlation indicators can provide an objective basis for TCM syndrome differentiation,which is conducive to more accurate clinical syndrome differentiation.3.Clinical detection of hs-CRP level is of positive significance to the diagnosis of TCM syndrome types.For patients with diabetes,hs-CRP can be used as an indicator of long-term disease monitoring.4.For the observation of the syndrome type of diabetic peripheral neuritis,blood stasis runs through all the time,and the application of drugs for promoting blood circulation and removing blood stasis is very important.at the same time,different effects of traditional Chinese medicine should be comprehensively considered according to the different causes of blood stasis.