Clinical Observation Of BI-RADS Grade3-4 Breast Hyperplasia By Acupuncture Based On Meridian Differentiation

Objective To observe the synergistic effect of acupuncture based on meridian on patients with bi-rads grade 3-4 breast hyperplasia.Methods This study is a parallel controlled trial,designed strictly in accordance with the requirements of randomized control,and implements the double-blind principle for evaluators and statisticians.The 72 patients who met the inclusion criteria and were diagnosed as bi-rads grade 3 to 4 by b-ultrasound were divided into the control group and the treatment group according to the random number table method,with 36 cases in each group,of which 2 cases falls off in the treatment group and 1 case falls off in the control group.The treatment group was treated with acupuncture based on meridian differentiation based on oral drug therapy.the main point were Zusanli(ST36)and Sanyinjiao(SP6)Danzhong(RN17);the corresponding points are selected according to the type of syndrome,and the control group was treated with hongjinxiaojie capsules,take four pills three times a day.The subjects receive acupuncture treatment 3 times a week,and each menstrual cycle is a course of treatment.Three courses of treatment,statistical data before treatment,at the end of treatment,and follow-up once a month after the end of treatment,followed for three consecutive months,and then followed up six months and one year after the end of treatment.Observation indicators were formulated according to the 8th Academic Conference of the Breast Disease Professional Committee of the Chinese Academy of Chinese Medical Surgery(2002),which discussed and revised the "Diagnosis,Syndrome,and Efficacy Evaluation Standards for Breast Hyperplasia",Develop breast tumor size,tumor hardness,breast pain and mass as the main observation indexes,and the results of breast ultrasound.In addition,closely observe and record adverse reactions and adverse events caused by drugs or acupuncture during the study.The data obtained from the research after collation were summarized and analyzed by SPSS 24.0 software.Results(1)Baseline analysis Age comparison(p = 0.85),course comparison(p = 0.76),breast pain comparison(p= 0.67),mass size comparison(p = 0.76),mass range comparison(p = 0.72),mass hardness comparison(p = 0.85)After comparison of age,course of disease,clinical symptom score,color Doppler ultrasound,and pain scale,the differences were not statistically significant(p values were all greater than 0.05),and the data were comparable.(2)Comparison of comprehensive efficacy between the two groups(1)Comparison of the overall efficacy of the treatment group: the total effective rate after treatment was 91.17%(3 of them were cured,12 were significantly effective,16 were effective,and 3 were ineffective);(2)Comparison of the overall efficacy of the control group: the total effective rate after treatment was 85.71%(of which 1 case was cured,5 cases were markedly effective,24 cases were effective,and 5 cases were ineffective);(3)Comparison of the comprehensive effect between the control group and the treatment group after treatment(z =-2.244)(p = 0.02),where the p value is less than0.05,the difference is statistically significant,so that the comprehensive effect of the treatment group is better than the control group.(3)Comparison of clinical symptom scores between the two groups(1)After the end of treatment,the total score of the clinical symptoms of the control group and the treatment group was compared,in which the total clinical score of the control group after treatment was: 17.17 � 9.04;the total clinical score of the treatment group after treatment was: 12.14 � 7.60;two independent Sample non-parametric test,P = 0.032,P value was less than 0.05,the results show statistical significance.(2)The comparison between the control group and the treatment group for each clinical symptom score group was performed using the rank sum test:A Treatment group :Before treatment,the breast pain score was 15.18 6.97;after treatment,it was4.24�5.63 Z=-5.511,P=0.The score of the mass hardness before treatment was 5.47�2.02,and after treatment was 2.47�2.27 Z=-4.849,P=0.Before and after treatment,the tumor size was 3.79�1.86 and 3.00�1.28Z=-1.801,P=0.07,.Before and after treatment,the tumor range integral was 3.26�0.86 and 2.74�1.12Z=-2.106,P=0.035.Conclusion:The symptom scores in the group were compared,the P value of breast pain,mass,and range score was less than 0.05,the difference was statistically significant;the P value of breast mass size score was greater than 0.05,the difference was not statistically significant.It shows that the treatment group is significantly better than the control group in improving clinical symptoms.B control group:Before and after treatment,the breast pain score was 15.43�7.32 and 7.71�7.21Z=-4.353,P=0.The score of the mass hardness before treatment was 5.40 2.16,and after treatment was 3.17 2.29 Z=-3.897,P=0.Before and after treatment,the tumor size was 3.94�2.03 and 3.26�1.34 Z=-1.605,P=0.108.Before and after treatment,the tumor range integral was 3.34�0.97 and 3.00� 0.74z=-1.646,P=0.100.conclusion:The symptom scores in the group were compared,in which breast pain and mass score P value were less than 0.05,the difference was statistically significant;breast mass size,range score P value was greater than 0.05,the difference was not statistically significant.(4)The grading analysis of breast color ultrasound(1)Comparison between control group and treatment group on bi-rads grading of breast color ultrasound.After treatment,the breast color doppler ultrasound grading results of the control group and the treatment group were compared by rank sum test.Results: Z =-1.283,P= 0.200,compared with control group and treatment group,P> 0.05,the difference was not statistically significant.(2)Comparison of bi-rads classification of breast color Doppler ultrasound in control group and treatment group After treatment,the comparison of BI-RADS classification of breast color Doppler ultrasound in the control group was Z =-0.538,P = 0.59,P> 0.05,and the difference was not statistically significant.Comparison of BI-RADS classification of breast color Doppler ultrasound in the treatment group before and after,Z =-1.907,P = 0.057,P>0.05,the difference was not statistically significant.Conclusion Acupuncture therapy based on meridians differentiation and oral hongjinxiaojie capsule can significantly improve the clinical symptoms of patients diagnosed by breast color ultrasound as bi-rads3-4 grade breast hyperplasia.The results showed that acupuncture therapy based on meridians differentiation combined with oral hongjinxiaojie capsule had a synergistic effect on patients with bi-rads3-4 grade breast hyperplasia.