Clinical Study Of Jiajian Pingfei Decoction In Treating Chronic Obstructive Pulmonary Disease Patients With Deficiency Of Pulmonary And Kidney Qi

Objective:To observe the clinical effect of Jiajian Pingfei Decoction on patients with chronic obstructive pulmonary disease in the stable stage of lung and kidney qi deficiency,to confirm the feasibility of Jiajian Pingfei Decoction in treating chronic obstructive pulmonary disease,which is the stable period of chronic obstructive pulmonary disease The treatment provides a new Chinese medicine treatment method.Methods:In this study,patients with Western medicine diagnosed as chronic obstructive pulmonary disease in a stable period,and the syndrome differentiation of traditional Chinese medicine with lung and kidney qi deficiency were included in the study.A total of 73 cases were included.They were randomly divided into a control group and a treatment group,of which There were 37 cases in the control group and 36 cases in the treatment group.The treatment plan of the control group should be treated with salmeterol ticasone inhalation,and the treatment group should be given orally with Chinese medicine decoction plus Jianpingpingfeitang on the treatment plan of the control group.The treatment period of both groups was 4 weeks.After 4weeks,the control group and the treatment group were compared with the individual scores of TCM syndromes,the total scores of TCM syndromes,CAT score,clinical efficacy,and lung function improvement?FVC,FEV₁,FEV₁/FVC%?And changes in serum LTB-4,IL-8 and other indicators,and verify the safety indicators such as liver and kidney function,in order to evaluate the clinical efficacy of Jiajian Pingfei Decoction.Results:1.Comparison of single scores of TCM syndromes:After 4 weeks of treatment,the single scores of five TCM syndromes of the two groups of patients including wheezing,shortness of breath,fatigue,cough,and sputum decreased compared with before treatment?P<0.05?.The single points of TCM syndromes decreased significantly compared with the control group?P<0.05?;after treatment,the single points of TCM syndromes such as spontaneous sweating,waist and knee soreness,tinnitus decreased in the treatment group compared with before treatment?P<0.05?,the control group After the treatment,there was no decrease?P>0.05?.2.Comparison of the total score of TCM syndromes:After 4 weeks of treatment,the total score of TCM syndromes in both groups decreased compared with before treatment?P<0.05?,and the total score of TCM syndromes in the treatment group decreased significantly compared with the control group?P<0.05?.3.Pulmonary function comparison:After 4 weeks of treatment,the lung function indexes?FVC,FEV₁,FEV₁/FVC%?of the control group and the treatment group increased compared with before treatment?P<0.05?,and the lung function indexes of the treatment group increased compared with the control group Obvious?P<0.05?.4.Comparison of CAT score:After 4 weeks of treatment,the CAT score of the two groups of patients decreased compared with before treatment?P<0.05?,and the CAT score of the treatment group decreased more than the control group?P<0.05?.5.Comparison of serum LTB-4 and IL-8:After 4 weeks of treatment,the serum LTB-4 and IL-8 levels of the two groups were lower than before treatment?P<0.05?,and the serum LTB-4 and IL-of the treatment group 8The degree of decrease was more obvious than that of the control group?P<0.05?.6.Comparison of the effectiveness of traditional Chinese medicine:After 4weeks of treatment,the control group showed 14 cases,12 cases were effective,and 9 cases were ineffective,with a total effective rate of 74.2%.In the treatment group,22 cases were markedly effective,11 were effective,and2 cases were ineffective.The total effective rate was 94.2%The effective rate of the treatment group was higher than that of the control group?P<0.05?.7.Safety observation:During the 4-week clinical treatment,no obvious abnormalities of liver and kidney function were observed in any patients.Conclusion:1.The application of Jiajian Pingfei Decoction in the treatment of chronic obstructive pulmonary disease patients with stable lung and kidney qi deficiency syndrome has a good effect.2.Jiajian Pingfei Decoction can significantly alleviate the clinical symptoms of chronic obstructive pulmonary disease stable lung and kidney qi deficiency patients,improve quality of life,improve lung function,reduce serum LTB-4and IL-8 levels,and reduce inflammation damage.As an effective prescription for patients with chronic obstructive pulmonary disease and stable lung and kidney qi deficiency syndrome.3.The observation of this study shows that the clinical use of Jiajian Pingfei Decoction is safe and has no obvious toxic and side effects.