| Background Acute cerebral infarct(ACI),also known as acute ischemic stroke(AIS),is a common disease with high disability and lethality which threatens human life seriously.Our country bears the largest burden of stroke in the world,so active prevention and treatment of acute cerebral infarction cannot be delayed.Red blood cell distribution width(RDW)is a conventional parameter of blood routine,which reflects the size of red blood cell heterogeneity,and is mainly used for the diagnosis of anemia.Previous studies have shown that there is a strong correlation between RDW and cerebral infarction,which has important value in the assessment of ACI risk,diagnosis,and prognosis.Many scholars had tried to combine S100 B with other biomarkers to improve the sensitivity of ACI diagnosis,but there are few studies on S100 B combined with RDW.Therefore,this study aimed to improve the diagnostic value of ACI through combine that two biomarkers,RDW and S100 B.Objective To detect the levels of RDW and serum S100 B in patients with ACI and explore the correlation between these two biomarkers with other parameters of ACI in order to find reliable biomarkers for early screening and evaluation in clinical diagnosis and treatment.Methods A total of 223 patients diagnosed with ACI and treated in the Department of Neurology,Xinxiang Central Hospital from May 2018 to December 2019 had been recruited.Their basic clinical data such as age,gender,and previous history(hypertension,diabetes)of these patients also had been recruited at the same time.All patients were confirmed by CT or MRI and divided into two groups,ACI group and non-ACI group.There were 108 patients in the ACI group,64 males and 44 females,with an average age of 63.91 ± 11.41 years.The neurological deficits were scored and grouped according to the National Institutes of Health Stroke Scale(NIHSS)(The patients with scored ? 11 points in NIHSS divided into low scores group and NIHSS >11 were divided into high scores group).Also,there were 115 non-ACI patients,62 males,and 53 females,with an average age of 62.66 ± 11.34 years.Fasting venous blood was collected in the early morning and blood routine was analyzed for RDW parameters in these two groups of patients.Serum S100 B protein was determined by enzyme-linked immunosorbent assay(ELISA).The basic medical parameters of patients were also collected.SPSS 25.0 software was used for statistical analysis and P < 0.05 was considered statistically significant.Results 1.There were significant differences in RDW,S100 B,WBC,PLT,LDL,and HDL between ACI group and non-ACI group(P< 0.05),and there were no significant differences in age,sex,TC,TG,Cys-C,diabetes and hypertension(P > 0.05).2.Bivariate logistic regression analysis was conducted with RDW,WBC,PLT,LDL and HDL as independent variables.The results showed that RDW,WBC and LDL were risk factors for ACI(OR=2.804,OR=1.245,OR=1.635,P < 0.05).3.There were significant differences in RDW,S100 B,and LDL between low and high NIHSS score groups(P < 0.05),and there were no significant differences in age,sex,diabetes,hypertension,WBC,PLT,TC,TG,LDL and Cys-C(P > 0.05).4.Person correlation analysis was used to analyze the correlation between RDW and S100 B and NIHSS score.The results showed that there was a positive correlation between them,and the difference was statistically significant(r=0.489,P < 0.05;r=0.587,P < 0.05;r=0.229,P < 0.05).5.ROC curve analysis showed that the area under the cure of RDW was 0.723(95% CI:0.657-0790,P < 0.001).The area under the cure of S100 B was 0.867(95% CI:0.821-0.914,P < 0.001).The area under the cure of RDW and S100 B was 0.892(95% CI:0.850-0.933,P < 0.001).Conclusions The higher the RDW and S100 B levels,the more severe the acute cerebral infarction;the combined RDW and S100 B test has predictive value in assessing the severity of clinical acute cerebral infarction. |
PDF Full Text Request