Application Of Resting State Functional Magnetic Resonance Imaging In Patients With Memory Impairment After Craniocerebral Injury

BackgroundCraniocerebral injury,as a common disease in neurosurgery,is often complicated many complications such as dysfunction and cognitive impairment,has caused a long-term negative impact on the body and mind.The main clinical manifestation of cognitive impairment after craniocerebral injury is memory loss.At present,the detection and diagnosis of memory disorder patients after craniocerebral injury is mainly based on neuropsychological scale,and its test results lack some objectivity.In recent years,resting state functional magnetic resonance imaging has been more and more used in the study of cognitive impairment after craniocerebral injury,and its pathogenesis has been gradually revealed by researchers.However,few resting-state functional magnetic resonance imaging studies mainly focus on memory impairment after craniocerebral injury have been carried out,and the mechanism has not been fully revealed.ObjectiveUsing resting-state functional magnetic resonance imaging to observe the changes of brain amplitude of low frequency fluctuation and regional homogeneity in patients with memory impairment after craniocerebral injury and to explore the neural mechanism of brain activity MethodsAccording to the inclusion criteria and exclusion criteria,10 patients with memory impairment after traumatic brain injury and 10 patients without memory impairment after traumatic brain injury were selected from the neuros inpatients in our hospital fromNovember 2018 to October 2019.At the same time,10 healthy volunteers with age and sex matching and score greater than 90 after testing by the Wechsler memory scale were recruited from the family members of inpatients and the periphery of the hospital for resting state functional magnetic resonance scanning.Amplitude of low frequency fluctuation analysis was used to compare the changes of the three groups of subjects ALFF value.The whole brain ReHo was obtained by calculating the similarity between each given voxel and its nearest 26 voxel time series,and the difference of the whole brain ReHo value of the three groups was compared.ResultsIn memory disorder after brain injury group,ALFF values were lower in left anterior cingulate gyrus compared with health control group(p<0.001).Between the healthy control group and the memory-free group after brain injury,the memory-free group after brain injury and the memory-impaired group after brain injury had no significant difference(p>0.001).In memory-free group after brain injury,ReHo values were lower in left angular gyrus compared with healthy control group(p<0.001).In memory disorder after brain injury group,ReHo values were lower in left angular gyrus and left anterior cingulate gyrus and left gyrus frontalis medius compared with healthy control group(p<0.001).In memory disorder after brain injury group,ReHo values were lower in left gyrus frontalis medius compared with the memory-free group after brain injury(p<0.001).ConclusionsThe decrease of ReHo values in the left gyrus frontalis medius is associated with memory diaorder after traumatic brain injury,and the decrease of spontaneous activity consistency of left gyrus frontalis medius neurons may be one of the neural mechanisms of memory disorder in patients with traumatic brain injury.