The Value Of Resting State Functional Magnetic Resonance Imaging In Patients With Cognitive Dysfunction After Moderate Traumatic Brain Injury

BackgroundTraumatic brain injury(Traumatic brain injury,TBI)is a common neurosurgical disease,refers to the role of violence in the head caused by brain tissue organic damage.Domestic and foreign literature has pointed out that cognitive dysfunction is one of the most common and long-lasting sequelae after traumatic brain injury.At present,the diagnosis of traumatic brain injury associated with cognitive dysfunction and more stay in the cognitive function rating scale and other subjective methods,which lack of support for objective evidence.FMRI has been widely used in the study of neuropsychiatric diseases because of its clear and noninvasive display of changes in the structure and function of the brain.In recent years,there are more studies on the changes of functional magnetic resonance imaging in cognitive dysfunction after mild craniocerebral injury,However,in patients with moderate craniocerebral injury as the research object,it is seldom studied to investigate the brain functional changes in patients with cognitive impairment after craniocerebral injury.ObjectiveTo investigate the value of resting state functional magnetic resonance imaging in patients with cognitive impairment after moderate traumatic brain injury.MethodsWe collected 43 patients with traumatic brain injury in our hospital from May 2016 to December 2017,according to inclusion and exclusion criteria,a total of 37 patients were included in this study.About 10 days after injury,Minimum mental state examination(Minimum mental state examination,MMSE)scores were used to determine if there were cognitive impairment,divided into craniocerebral injury patients with cognitive dysfunction group of 24 patients,13 patients with normal cognitive function after craniocerebral injury;at the same time recruit 10 healthy people as a control group.The ALFF changes of the three groups were analyzed by using amplitude of low frequency fluctuation(Amplitude of low frequency fluctuation,ALFF)analysis method of resting state magnetic resonance.ResultsThere was no significant difference between the three groups in age,sex,years of education(P> 0.05).There was significant difference in MMSE scores among the three groups(P<0.001).The MMSE scores in the cognitive impairment group after craniocerebral injury were significantly lower than those in the cognitive normal group and normal control group after craniocerebral injury(P <0.05).ALFF difference between the three groups of brain areas for left fusiform,left superior frontal gyrus,left inferior frontal gyrus,left inferior parietal lobule.Compared with the healthy control group,the brain regions with ALFF value increased in the two cases were located in the left hemisphere,left fusiform,left superior frontal gyrus,left inferior frontal gyrus,the brain Compared with the normal cognitive function group after injury,the brain area with reduced ALFF value was the left inferior parietal lobule.ConclusionsThere were multiple brain regions with resting low frequency amplitude anomalies in the early stage of traumatic brain injury in patients with moderate traumatic brain injury.The change of ALFF value in resting brain state functional magnetic resonance imaging can provide some reference value for the early diagnosis of cognitive impairment after traumatic brain injury.