Study Of Resting State FMRI On Abnormal Low Frequency Amplitude And Functional Connection Of Post-traumatic Headache After Mild Traumatic Brain Injury

Objectives:To detect the abnormalities of low frequency amplitude(ALFF)and functional connectivity(FC)in patients with post-traumatic headache(PTH)after mild traumatic brain injury(mTBI)by resting state functional magnetic resonance imaging(rs-fMRI),and to analyze the correlation between these abnormal brain function changes and clinical data,and to explore the relationship between abnormal FC and cognitive function in patients with mTBI.And whether there are potential clinical indicators that can be used to detect the brain function of patients with PTH after mTBI.Methods:35 patients with PTH after mTBI and 20 healthy controls(HC)matched with age,sex and education were tested with neuropsychological scales and MRI datas were collected,including rs-fMRI and 3D-T1WI.To obtain abnormal ALFF regions of patients with PTH after mTBI.Then these regions are used as seed points of interest to calculate the functional connection(FC)between the region of interest(ROI)and the whole brain to evaluate the change in network level.Spearman correlation analysis was used to detect the correlation between fMRI information and clinical datas.Results:Compared with the HC,the ALFF signal of right fusiform gyrus in PTH patients after mTBI was significantly decreased,while the ALFF signal of left medial superior frontal gyrus,right medial and paracingulate gyrus,right dorsolateral superior frontal gyrus was significantly increased,and the change of ALFF signal in right fusiform gyrus was related to the subcategory-visual space-execution ability in MoCA(P<0.05).The FC between the right medial and para-cingulate gyrus and the left medial superior frontal gyrus and right rectus gyrus decreased,while the FC between the right anterior lobe,right superior marginal gyrus,right thalamus and right medial and lateral cingulate gyrus increased.The abnormalities of FC in these brain regions were related to some clinical data of the patients(P<0.05).Conclusion:The current results of this study further deepen the understanding of patients with PTH after mTBI.The brain regions with abnormal ALFF signal and the abnormal brain network of FC in patients with PTH after mTBI are directly or indirectly related to cognitive function,suggesting that the cognitive function of patients with PTH after mTBI is abnormal in varying degrees,indicating that the change of brain functional network is the basis of cognitive impairment in patients with PTH after mTBI.These changes can be used as biomarkers of brain function defects in patients with PTH after mTBI,which can be used to detect and guide clinical intervention.Rs-fMRI provides an objective imaging method for the diagnosis,treatment and prognosis of patients with PTH after mTBI.