Meta Analysis Of The Clinical Manifestations And Prognosis In Endometriosis Associated Ovarian Cancer

ObjectiveTo compared the clinical manifestations and prognosis of primary epithlial ovarian cancer and endometriosis associated ovarian cancer in order to provide evidence-based medical support for the clinical diagnosis and treatment of the disease.MethodsThe relevant foreign language and Chinese databases were searched by computer to search the literatures related to endometriosis related ovarian cancer,and the literatures that met the requirements were selected according to the strict inclusion and exclusion criteria,and the included literatures were subject to data synthesis,quality evaluation and heterogeneity test.RevMan 5.3 statistical software was used to analyze the included literature data.ResultsFinally,37 articles were included in this study,including 29 articles in Chinese and 8 articles in English.The quality of each document was assessed in accordance with the criteria of the Ottawa scale.The final meta analysis shows that?1?EAOC patients were younger,with significant differences?MD=-4.53,95%CI?-5.38,-3.69?,P<0.00001?,?2?The age of menarche was earlier in EAOC patients.and the difference was significant?MD=-0.71,95%Cl?-1.35,-0.07?,P=0.03<0.05?.?3?Patients with EAOC had an early stage of FIGO tumor staging,and the difference was significant?OR=4.33,95%CI?3.22,5.84?,P<0.00001?,?4?Endometriosis associated ovarian cancer patients had a high degree of tumor differentiation,significant differences?OR=0.34,95%CI?0.20,0.57?,P<0.0001?,?5?The 5-year survival rate of patients with EAOC was significantly higher?OR=2.00,95%Cl?1.45,2.74?,P<0.0001?,?6?The difference didn't exist in tumor diameter between the two groups?OR=1.53,95%Cl?0.58,4.02?,P=0.39>0.05?,?7?There is no difference in delivary times between the two groups?OR=1.21,95%Cl?0.81,1.81?,P=0.36?.?8?The difference didn't exist in the symptoms of abdominal pain of the two groups?OR=0.77,95%Cl?0.52,1.16?,P=0.21>0.05?,?9?Abdominal distension showed no difference between the two groups?OR=0.77,95%Cl?0.48,1.25?,P=0.29>0.05?,?10?The incidence of dysmenorrhea in EAOC patients was higher and the difference was obvious?OR=2.64,95%Cl?1.66,4.19?,P<0.0001?,?11?EAOC patients are more prone to infertility symptoms,the difference is significant?OR=10.50,95%CI?2.29,48.95?,P<0.002?,?12?The incidence of menstrual changes in EAOC patients was higher and the difference was significant?OR=2.97,95%CI?2.29,3.87?,P<0.00001?,?13?EAOC patients had less ascites,and the difference was obvious?OR=0₃6,95%CI?0.24,0.53?,P<0.00001?,?14?There was no difference between the two pelvic masses?OR=1.07,95%Cl?0.67,1.73?,P=0.77>0.05?,?15?There was no difference in vaginal bleeding between the two groups?OR=1.62,95%CI?0.94,2.80?,P=0.08>0.05?,?16?EAOC patients were less likely to have menopause,and the difference was significant?OR=0.54,95%Cl ??0.31,0.93?,P=0.03<0.05?,?17?The serum CA125 concentration of EAOC patients was between 35-200u/ml,while that of OC patients was above 200U/ml,with a significant difference?OR=2.90,95%CI?1.46,5.74?,P=0.002<0.05?.Conclusion1.Compared with primary epithelial ovarian cancer,endometriosis associated ovarian cancer is characterized by young age,early menarche age,early FIGO stage,high degree of tumor differentiation,and high 5-year survival rate.2.In terms of clinical manifestations and prognosis,endometriosis associated ovarian cancer is more prone to dysmenorrhea,infertility and menstrual changes,and relatively less prone to ascites and menopause.3.Endometriosis associated ovarian cancer and primary epithelial ovarian cancer did not show significant differences in tumor diameter,number of births,pelvic mass,abdominal pain,abdominal distension,and vaginal bleeding.