Study On TCM Syndromes Of Pulmonary Nodules And Analysis Of Related Factors

Objective:To study the distribution of TCM syndromes of pulmonary nodules,analyze their influencing factors,pave the way for standardization of syndromes in pulmonary nodules,and provide ideas for early intervention of Chinese medicine.Methods:From January 2019 to December 2019,all patients with pulmonary nodules who were in the Multi-disciplinary Pulmonary Nodules Clinic of Jiangsu Provincial Hospital of Traditional Chinese Medicine,were hospitalized with lung puncture biopsy,and were hospitalized with thoracoscopy for thoracic surgery were included.Collect their clinical information(gender,age,smoking history,personal tumor history,family tumor history,etc.)and nodular characteristics(size,number,density,location),and perform TCM differentiation based on diagnostic information(symptoms,signs,tongue and veins).The collected data was sorted into an Excel spreadsheet and analyzed with SPSS 24.0 statistical software.For all patients with pulmonary nodules,analyze the correlation between nodular pathology,number of nodules and distribution of TCM syndrome types;for patients with solitary pulmonary nodules,analyze the correlation between age,gender,nodule density,nodule size and distribution of TCM syndrome typesResults:?A total of 803 patients with pulmonary nodules were included in this study,including 329 males and 474 females.The ratio of male to female was about 1:1.44,and the average age was 54.55±12.05.The total number of cases in the middle-aged group and the elderly group accounts for about 80%,and there are more female patients in each age group.?Of the 803 patients with pulmonary nodules,including 184 cases with no symptoms(22.9%)>Liver stagnation syndrome in 153 cases(19.1%)>Spleen deficiency and phlegm dampness syndrome in 134 cases(16.7%)>Spleen and stomach dampness heat syndrome in 96 cases(12.0%)>Liver depression fire syndrome(10.8%)>Phlegm and blood stasis syndrome in 86 cases(10.7%)>Deficiency of qi and yin in 63 cases(7.8%).?The common symptoms of patients with pulmonary nodules include irritability(60.15%),anxiety(43.34%),dry mouth(36.99%),poor range(34.37%),fatigue(32.88%),belching(26.15%),cough(23.66%),kindness(22.91%),and abdominal distension(20.92%)are mainly related to bad mood and sleep problems.?There were 292 cases with clear pathology,including 100 benign nodules and 192 malignant nodules.Atypical adenoma-like hyperplasia(AAH),fibrous nodules,and granulomas were common in benign nodules.88.5%of malignant nodules Early lung adenocarcinoma.There was no significant difference in the distribution of the syndrome types between the benign group and the malignant group(P>0.05);however,there were significant differences in the distribution of phlegm and blood stasis syndrome between the two groups(P<0.05),and the proportion of phlegm and blood stasis syndrome distribution in the malignant group(46.3%)was higher than that in the benign group(24.3%).?In this study,there were 452 patients with multiple pulmonary nodules and 351 patients with solitary pulmonary nodules(SPN).There were significant differences in the distribution of syndrome types between the two groups(P<0.05),and the proportion of patients with spleen and stomach dampness and heat syndrome in the multiple group(15.5%)was significantly higher than that in the single group(7.4%).?For patients with solitary pulmonary nodules(SPN),the distribution of TCM syndrome types was significantly different between different ages and different nodule size groups(P<0.05);the distribution of TCM syndrome types was not significant among different gender and different nodule density groups(P>0.05).Conclusions:Pulmonary nodules are more common in middle-aged and older people,and the incidence is higher in women than in men.Patients with pulmonary nodules often have bad mood and sleep problems.The distribution of TCM syndromes is mostly empirical.The pathological factors are mainly qi stagnation and deficiency.Phlegm dampness,damp heat,stagnation fire and phlegm stasis are all involved.AAH,fibrous nodules and granuloma were common in benign nodules and early adenocarcinoma was dominant in malignant nodules.The distribution of TCM syndromes of pulmonary nodules has no correlation with the pathology of nodules,but patients with phlegm and blood stasis are more likely to be malignant than asymptomatic.Patients with spleen and stomach dampness-heat syndrome are more likely to have multiple nodules.The distribution of TCM syndromes of SPN is related to age and nodule size,but not to gender and nodule density.