Research On The Prescriptions Of Wang's Wang's Lianpu Decoction

Objective:This article will sort out the prescription information of Wang's Lian Decoction,and use data mining technology to analyze the medical records reported in modern clinics to study the diseases,syndromes,tongue,pulse,Drugs and other information,as well as the impact area,season of onset,patient gender,patient age and other related factors on the use of Wang's Lianpu Decoction.On this basis,with the help of network pharmacology research technology,we will further explore the characteristics of Wang's Lianpu Decoction and the rules of clinical use,especially the mechanism of Wang's Lianpu Decoction 's treatment of chronic gastritis,and provide relevant research for this party Reference,with a view to improving the pertinence of the party's clinical application.Method:The first chapter is the research on the syndrome theory of Wang's Lianpu Decoction,summarizing the relevant articles of the life of the disease specialist Wang Meng Ying,the provenance of Wang's Lianpu Decoction's prescription,Wang's Lianpu Decoction function,Wang ' s Lianpu Decoction,To guide the clinical rational use of drugs.The second chapter is the research of modern medical records of Wang's Lianpu Decoction,with "Wang's Lianpu Decoction" as the key word,through the search of CNKI,VIP and CBM databases,to collect all the treatment of variousdiseases using Wang's Lianpu Decoction Clinical reports and the medical records included in the study through the inclusion and exclusion criteria specified in this article,using the Microsoft Excel worksheet of Microsoft Corporation to establish the medical record database for this study.Using frequency statistics method and cluster analysis method,summarizing Wang's Lianpu Decoction prescription syndrome,Western medicine disease spectrum,symptoms and diagnostic criteria of tongue and pulse,the original prescription drugs and the rule of addition and subtraction of drugs.The third chapter is the network pharmacology research of Wang's Lianpu Decoction's.Constructing the network structure of "Wang's Lianpu Decoction-target-chronic gastritis",and explaining Wang ' s Lianpu Decoction's treatment of chronic gastritis from a theoretical perspective Mechanism.Results:(1)General rules of use: The most used season of Wang's Lianpu Decoction is spring and autumn;The scope of use includes pediatric,internal,external,gynecological and other departments.The age of medication is mainly young and middle-aged,and there is no significant difference in sex ratio.The main area of use is central China.(2)Core pulse and syndrome: As the diagnostic criteria for secondary symptoms of Wang's Wang ' s Lianpu Decoction.The tongue image of Wang's Lianpu Yin syndrome uses red tongue and yellow fur as the diagnostic criteria;the pulse image uses “Hua” as the main diagnostic standard,and the composite pulseimage uses “Huashuo”,RuShuo,and “XianHua” as the main diagnostic criteria.(3)The original prescription medication rules: 60 cases of Wang's Lianpu Decoction in clinical use Coptis chinensis,Magnolia officinalis,Pinellia,Gardenia are essential drugs used by the side,and the other drugs are used more frequently: Shichangpu,Lugen,Poria,Citrus aurantium,tempeh.(4)Regularity of addition and subtraction of medicines: A total of 139 flavored medicines were included in the medical record,with a total of 417 times of use.The top ten flavored medicines that appeared frequently were: Poria,Citrus aurantium,Licorice,Coix seed,Scutellaria baicalensis,Orange peel,malt,patchouli,almond,talc.(5)TCM disease spectrum:Wang's Lianpu Decoction has a wide range of TCM disease syndromes,and a total of 32 diseases are involved in the medical record.The main syndromes are spleen and stomach syndromes,Qixuejinjin syndromes,and the main diseases involved are stomach pain,ruffling,and constipation,Diarrhea,malaria,nausea,vomiting,etc.(6)Western medicine disease spectrum: In the selected medical records,there are a total of 28 kinds of Western medicine diseases,including digestive system,nervous system,respiratory system,urinary system,infectious diseases,otolaryngology,endocrine system,gynecological diseases,skin system,reproductive system,Cardiovascular system,orthopedics,stomatology diseases13 categories.The main diseases involved are acute,chronic gastritis,dyspepsia,and neurosis.(7)The highest active ingredients in Wang's Lianpu Decoction are quercetin,kaempferol,baicalein,and beta-sitosterol.Its core targets for the treatment of chronic gastritis include IL-1 ?,IL-2,VEGFA,JUN,RB1,CDKN1 A,FOS,HSP90AA1,IL6,TP53,MYC *,MAPK1,MAPK14,CCND1,AKT1,etc.The signal pathway is: NF-? B signaling pathway,PI3K-Akt signaling pathway,NOD-like receptor signaling pathway,Toll-like receptor signaling pathway,Helicobacter pylori infected epithelial cell signal transduction,etc.Conclusion:(1)The dominant disease of Chinese medicine in Wang's Lianpu Decoction is the syndrome of spleen and stomach,which mainly includes stomach pain and fullness.(2)The dominant disease of Wang's Lianpu Decoction's Western medicine is digestive system diseases,including gastritis.(3)The clinical application of Wang's Lianpu Decoction is gastrointestinal tract,stomach pain,indigestion and other manifestations.The tongue is mostly red tongue,and the tongue coating is mostly yellow and greasy.(4)Wang's Lianpu Decoction has the pharmacological characteristics of multi-target and multi-channel treatment of chronic gastritis.In theory,the prescription has an intervention effect on the complex pathological mechanism of chronic gastritis.