Study On Clinical Characteristics Of Bronchiectasis Complicated With Lung Cancer And Association Between Them

Objective:To study the clinical characteristics of bronchiectasis combined with lung cancer,to explore the risk factors and pathological types of lung cancer,and to study the correlation between bronchiectasis and the location of lung cancer,so as to provide ideas and basis for the diagnosis of lung cancer.Methods:56 patients with bronchiectasis complicated with lung cancer and 112 patients with bronchiectasis hospitalized in our hospital were selected.Age,sex,smoking history,hospitalization days,clinical manifestations,hematological examinations,CT imaging findings,pathological types of patients were collected,and their clinical characteristics were analyzed retrospectively.Results: Among 1058 patients with bronchiectasis diagnosed in hospital during 8 years,there were 56 patients with lung cancer in the study group,accounting for 5.3%,among them,35 patients aged ≥ 60 years,accounting for 62.5%,which was significantly higher than that in the control group(P < 0.05).The average length of hospital stay in the study group(14.54 ± 8.90)was higher than that in the control group(9.33 ± 5.66)(P< 0.05).The smoking history and smoking index(≥ 400 / year)in the study group were significantly higher than those in the control group(P < 0.05).The clinical manifestations of chest distress,shortness of breath,chest pain and decreased breath sound in the study group and the proportion of mass,cavity and atelectasis in the lung CT,as well as the antigens of squamous cell carcinoma,carcinoembryonic antigen and cytokeratin 19 fragment in the study group were higher than those in the control group(P < 0.05).In the study group,squamous cell carcinoma accounted for 50%,adenocarcinoma 33.9%,small cell carcinoma 7.1% and others 9.0%.The proportion of squamous cell carcinoma in male(89.3%)was significantly higher than that in female(10.7%)(P < 0.05).According to lung CT,each patient was recorded as having 6 lobes.In the study group,56 patients involved336 lobes.Lung cancer lesions were mainly distributed in the upper lobes,accounting for50.8% of the total.Bronchiectasis was mainly located in the lower lobes,accounting for59.5%;in the control group,112 patients involved 672 lobes,and bronchiectasis was mainly located in the lower lobes,accounting for 59.5%.When binary logistic regression analysis is used to evaluate the relationships between the location of bronchiectasis and lung cancer,the OR value is 1.618(95% CI: 0.948—2.980),P = 0.075.Conclusion:The clinical symptoms and signs of the two groups were similar.We should be alert when the patients with bronchiectasis had chest tightness,shortness of breath,chest pain,decreased breath sound,the lung CT showed mass,cavity and atelectasis changes,and the tumor markers indicate the increase of squamous cell carcinoma antigen,carcinoembryonic antigen and cytokeratin 19 fragment antigen.Smoking index ≥ 400 / year may be the risk factors of lung cancer,patients with bronchiectasis complicated with lung cance had the highest proportion of squamous cell carcinoma,and the length of hospital stay was longer.Lung cancer accounts for a high proportion of patients with bronchiectasis,but There is no significant correlation between lung cancer and bronchiectasis in the location of the disease.