Correlation Between Frailty And Cognitive Function In The Elderly

Objective:To understand the detection of frailty elderly patients,analyze the influencing factors,and explore the correlation between frailty and cognitive decline in the elderly.Methods:A case-control method was used to select 214 patients(mean age74.24 ± 9.06 years)from the geriatrics department of our hospital from November 2018 to November 2019.They were divided into frailty groups based on the evaluation results(case Group),non-weak group(control group);Mini-mental State Examination(MMSE)to assess and analysis cognitive function and collect relevant data.Results:(1)The detection rate of frailty was 36%;77 patients in the frailty group with an average age of(78.19 ± 9.17)years;137 patients in the non-frailty group with an average age of(72.01± 8.23)years,the age was different between the two groups(P <0.05).(2)The proportion of widowed,sleep disorders,comorbidities,multiple medications,activities of daily living(ADL)dependence and cognitive decline in the frailty group was higher than that in the non-frailty group(P <0.05).The average value of glycated hemoglobin,D-dimer,and creatinine in the frailty group was higher than that in the non-frailty group(P <0.05).The average value of hemoglobin and total protein in the frailty group was lower than that in the non-frailty group(P <0.05).(3)Binary logistic regression analysis suggests that age,sleep disorders,comorbidities,multiple medications,ADL dependence,cognitive decline,glycated hemoglobin,and creatinine are risk factors for frailty(P<0.05);albumin is a protective factor(OR = 0.724,95% CI: 0.656-0.800,P <0.05).(4)Pace and grip strength affect cognitive function(P <0.05),and orientation and recall affect frailty(P <0.05).The level of frailty and MMSE score were negatively correlated(r=-0.521,P <0.05).Conclusions:(1)The detection rate of frailty elderly in hospital is36%.(2)Age,sleep disorders,comorbidities,multiple medications,ADL,cognitive decline,glycated hemoglobin,and creatinine are independent risk factors for frailty and albumin is a protective factor.(3)Frailty and cognitive function of the elderly affect each other.frailty is negatively correlated with cognition.The weaker we are,the worse our cognitive function.