| Objective:This study is based on the theory of "seven,five,three"odd number law of Xia Guicheng,a master of Chinese Medicine,The clinical symptoms,the changes of serum P,β-hCG,E2 and the dynamic monitoring of B-ultrasound at the critical time of pregnancy in patients with early threatened abortion were studied.On the basis of the good clinical effect of the treatment of premonitory abortion with the use of Hutaiyin,we creatively combined the theory of Xia Lao with Hutaiyin,and took the lead in the dynamic observation of the treatment of Hutaiyin at different critical points in the early pregnancy,and analyzed the correlation between various indicators and the outcome of pregnancy,so as to more accurately and deeply study the effect of Hutaiyin on the early premonitory abortion at different gestational weeks to improve the success rate of pregnancy.Method:From May 2018 to December 2019,5-6 weeks of gestation were selected from the gynecology clinic and ward of Nanjing Hospital of traditional Chinese Medicine Affiliated to Nanjing University of traditional Chinese medicine,Sixty patients with Early Threatened Abortion of spleen and kidney deficiency type were randomly divided into two groups:treatment group(Hutaiyin oral liquid+Dydrogesterone)and control group(Dydrogesterone),each with 30 cases.The treatment lasted for 12 weeks.Before and after the intervention,the symptoms of the two groups were dynamically observed.The serum levels of human chorionic gonadotropin(β-hCG),progesterone(P),estradiol(E2)and pelvic B-ultrasound embryo development were monitored before,7 weeks(50 days),10 weeks(70 days)and 12 weeks(3 months).At the same time,the related pregnancy outcomes were followed up.Spss20.0 statistical software was used to process and analyze the data.The dynamic changes of serum human chorionic gonadotropin(β-hCG),progesterone(P),estradiol(E2)were observed at the critical time points.The fetal development of pelvic ultrasound at the critical time points was analyzed.The correlation between various indicators and pregnancy was analyzed.To explore the therapeutic mechanism of Hutaiyin on early threatened abortion at different critical time points of gestation.Results:1.Both the treatment group and the control group can improve the level of serum sex hormone at the corresponding time point,and the changes of E2 and β-hCG are more obvious;both can reduce the TCM syndrome score at the corresponding time point,and improve the clinical symptoms.The treatment group is better than the control group in these two aspects.The difference was statistically significant(P<0.05).2.There was no significant difference between the treatment group and the control group in terms of fetal heart rate and fetal shape seen by B-ultrasound after treatment(P>0.05),but the success rate of early pregnancy in the treatment group was significantly higher than that in the control group.3.The serum P,E2 and β-hCG in the successful group were significantly different from those in the failure group(P<0.05).The serum sex hormone level in the successful group increased at the corresponding time point,and the β-hCG doubled well.The serum sex hormone level in the failure group increased slowly or even decreased at the corresponding time point.After treatment,serum P fluctuated at the corresponding time point,and serum E2,β-hCG were significantly different at the corresponding time point(P<0.05),which was more sensitive to adverse pregnancy.4.The scores of TCM symptoms in the successful group and failure group decreased at the corresponding time points(P<0.05).The scores of TCM symptoms in the successful group decreased more significantly in the 10th and 12th weeks of pregnancy,which was significantly different from the failure group(P<0.05).5.The curative effect of TCM symptoms of the treatment group is 93.33%,the control group is 86.67%;the comprehensive curative effect of the treatment group is 93.33%,the control group is 86.67%;After treatment,the treatment group was better than the control group in the comparison of the curative effect of TCM symptoms and comprehensive curative effect.6.The statistical analysis shows that the failure of early pregnancy and the adverse outcome of follow-up are mostly occured at 50 days,70 days,3 months,even 5 months and 7 months.This corresponds to Professor Xia Guicheng’s odd number law of "seven,five and three".Conclusion:The research shows that the time when the clinical symptoms appear or worsen and the time when the embryo stops developing of threatened abortion patients accords with the law of "seven,five,three"odd number.The therapeutic effect of Hutaiyin on the early threatened abortion with deficiency of spleen and kidney was significant at the critical time,which improved the clinical symptoms and the level of serum sex hormone.The results showed that the level of serum E2 andβ-hCG was sensitive to evaluate the clinical effect and predict the outcome of early threatened abortion.Moreover,there is no side effect in the treatment of early threatened abortion,which is worthy of clinical promotion. |
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