Clinical Study On Early Identification Of Pathogenic Bacteria By MALDI-TOF MS

Objective: To investigate the clinical value of matrix-assisted laser desorption ionization time-of-flight mass spectrometry(matrix-assisted laser desorption ionization-time of flight mass spectrometry,MALDI-TOF MS)system(short-term mass spectrometry)for early identification of pathogenic bacteria.Methods: Collect blood,sputum and urine samples corresponding to the patients with blood flow infection,lung infection and urinary system infection in our hospital from June to August 2019.The pathogen was identified by MALDI-TOF MS and vitek 2compact automatic bacterial identification instrument in parallel,and the identification time of the two methods and the adjustment of antibiotics before and after the final identification results were compared.Results: Mass spectrometry is 24 hours earlier than the traditional method(p < 0.05),26(55.3%)of blood flow infections,33(50.8%)of pulmonary infections and 31(43.7%)of urinary tract infections adjusted antibiotics after final identification,mass spectrometry can provide the basis of antibiotic adjustment earlier.Conclusions: Mass spectrometry can identify pathogenic bacteria in the early stage,provide valuable reference for the diagnosis and treatment of diseases,and is beneficial to the early accurate and reasonable use of antibiotics,which is of great significance to improve the prognosis of infected patients and reduce the unreasonable use of antibiotics.