A Cross-sectional Clinical Study Of Blood Lipid Levels And Imaging Grading Of Lumbar Intervertebral Disc Degeneration

Objective:To explore the correlation between blood lipid level and imaging grade of lumbar intervertebral disc degeneration,and to provide a clinical research basis for further research on the influence of abnormal blood lipid metabolism in the occurrence and development of lumbar intervertebral disc degeneration.Methods: Collect clinical data of patients with clinical symptoms of low back pain who were admitted to the Department of Spine Surgery,the First Affiliated Hospital of Nanhua University from January 1,2019 to December 31,2019.Collect general characteristics of patients: hospitalization data(including admission records,surgical records,imaging data,blood draw results),age,gender,body mass index(BMI),low density lipoprotein(LDL),high density lipoprotein(HDL),Triglyceride(TG),cholesterol(TC),smoking and drinking habits,low back visual analog score(VAS).A total of 321 adult patients were collected after screening through strict inclusion and exclusion criteria.Based on the signal intensity of the MRI T2-weighted median sagittal image,the degenerative lumbar disc degeneration(LDD)was evaluated according to the criteria for lumbar disc degeneration(Pfirrmann classification))Degree classification.Perform statistical analysis on relevant data,evaluate the univariate relationship between LDD and variables by t test and chi-square test,and finally,use statistical Logistic single factor and multivariate regression analysis to obtain statistically valuable indicators and construct predictions Model,and compare the area under the curve of the constructed prediction model to evaluate the prediction ability of the model.Results: A total of 321 cases that met the inclusion and exclusion criteria and complete data were collected.There were 133 patients in the lumbar intervertebral disc low-imaging grading group(group L),mean age � standard deviation(X � S)56.29 � 11.96),age Median 58 years old(28 ? 73),BMI(X � S kg / m2): 25.64 � 2.75;Imaging grading group of lumbar intervertebral disc(group H): 188 patients,mean age � standard deviation(X � S)is(56.74 � 12.1),the median age is 58 years old(23 ? 81),BMI(X � S kg / m2): 26.54 � 2.70.The t test was used for age and BMI between the two groups.The results suggest that there is no statistical difference in age between the two groups,there is a statistical difference between BMI(P <0.0001),low back pain score and lumbar disc degeneration magnetic resonance The severity of the classification is related.There was no statistically significant difference in sex,plasma TG and HDL classification between the two groups.Logistic univariate and multiple regression analysis show that the area of model 1 and model 2 of multiple logistic regression are 0.733 and 0.724,respectively,indicating that the model has a certain predictive effect.However,the area under the curve of Model 2 is not significantly different,so the predicted value of Model 2 is not significantly different.Conclusion: Serum high TC and high LDL are related to the severity of LDD imaging classification(Pfirrmann classification)and are independent risk factors for LDD high imaging classification.