Clinical Observation Of Invigorating Spleen For Benefiting Lung In Treating Patients With Syndrome Of Qi Deficiency Of Lung And Spleen In The Stable Stage Of Bronchiectasis

Objective:To observe the clinical efficacy of the method of invigorating spleen for benefiting Lung in the treatment of patients with bronchiectasis at the stable stage of syndrome of qi deficiency of lung and spleen,and to objectively evaluate its feasibility,effectiveness and safety,so as to make some beneficial exploration in improving the clinical symptoms of patients in the stable period and reducing the number of acute exacerbations.Methods:A randomized,controlled and prospective study was conducted to collect 60 patients with syndrome of qi deficiency of lung and spleen during the stable period of bronchiectasis in outpatient of respiratory department of Jiangsu Traditional Chinese Medicine Hospital from March 2018 to May 2019 and randomly divided them into treatment group and control group,with 30 patients in each group.The control group was given oral eucalyptus Limonene and Pinene enteric-coated soft capsules(2/day,l/day),and the treatment group was combined with the instructor's self-prepared invigorating spleen for benefiting lung decoction to add or subtract(1 per day,2/day,200ml/time).The treatment period was 8 weeks,and the observation follow-up period was 6 months.Before treatment,the scores of syndrome of traditional Chinese medicine,inflammation indexes,sputum culture results,liver and kidney function of the two groups of patients were recorded.After the treatment,the results of the above four items were recorded in order,and the number of acute exacerbations and adverse reactions during the observation period were recorded.The data were sorted and compared with statistical software.Results:1.Scores of syndrome of traditional Chinese medicine:Both the treatment group and the control group can improve the clinical symptoms of the patients after treatment(P<0.05);the treatment group can significantly improve the symptoms of cough,expectorate,shortness of breath,mental fatigue,tiredness,spontaneous sweating,appetite,stool(P<0.01);the control group can improve some symptoms of cough,sputum,shortness of breath,mental fatigue,tiredness(P<0.05),but has no obvious effect on improving symptoms of spontaneous sweating,appetite,and stool(P>0.05);the treatment group was better than the control group in improving clinical symptoms of the patients(P<0.05).2.Inflammatory markers:?leukocyte count:The leukocytel counts of the two groups of patients was basically normal before and after treatment,and the two groups of drugs had no significant effect on reducing the normal leukocytel count(both P>0.05).? High-sensitivity C-reactive protein:Both the treatment group and the control group can reduce high-sensitivity C-reactive protein after treatment(P<0.05);the treatment group is superior to the control group in reducing high-sensitivity C-reactive protein(P<0.05).3.Efficacy evaluation:After 8 weeks,there were 0 cases of clinical control,5 cases of obvious effect,23 cases of effective effect,and 2 cases of ineffective effect,with a total effective rate of 93.3%in the treatment group.There were 0 cases of clinical control,1 case of obvious effect,18 cases of effective effect,11 cases of ineffective effect,with a total effective rate of 63.3%in the control group.The treatment group was better than the control group(P<0.05).4.Acute exacerbation:During the 6-month observation and follow-up period,3 cases of acute exacerbations in the treatment group all improved after outpatient treatment,and the acute exacerbation rate was 10%;8 cases of acute exacerbations in the control group included 1 hospitalization,7 cases improved after outpatient treatment,The aggravation rate was 26.7%.Chi-square test showed statistically significant difference between the two groups(P<0.05).This shows that the drugs in the treatment group can effectively reduce the number of patients with acute exacerbations.5.Sputum culture results:Before treatment,there were 4 cases with positive results in the treatment group,19 cases with negative results,and 7 cases with no test;3 cases with positive results in the control group,17 with negative results,and 10 with unchecked;a small amount of leather was detected in the sputum of the two groups Gram-negative bacilli.After treatment,there were 1 positive result in the treatment group,22 negative results,and 7 unchecked patients;2 positive results in the control group,18 negative results,and 10 unchecked patients;there was no significant difference in sputum culture results between the two groups(P>0.05),the sputum.negative rate of treatment group and control group was 75%and 33%,respectively.6.Safety evaluation:Liver and kidney function tests were conducted in the two groups before and after treatment,which were in the normal range.Comparison between the two groups before and after treatment showed that P was>0.05,indicating that there was no significant difference in liver and kidney function results between the two groups before and after treatment.The effect was small,and no obvious adverse reactions were found in the treatment of the two groups.The safety assessment was level 1.Conclusion:By using the method of invigorating spleen for benefiting Lung to treat patients with bronchiectasis in the stable stage of syndrome of qi deficiency of lung and spleen,it can effectively improve their clinical symptoms such as cough,sputum,shortness of breath,mental fatigue,tiredness,spontaneous sweating,appetite,stool;for normal white blood cells The effect of counting is small;it can reduce the high-sensitivity C-reactive protein;it can help sputum to be negative;it can effectively reduce the number of acute exacerbations;and the drug has higher safety and the patient is more likely to receive treatment.