Study On The Synergistic Effect Of "Haishi" Sleep On IR-PCOS Patients Aged 11 To 24 Years

Objective:This study analyzes different sleep hour in the kidney and phlegm and metformin treatment peripuberty(age 11-24)IR-influence the curative effect of PCOS,on the efficacy of IR-PCOS in patients who are under the treatment of Wenshenhuatan recipe or metformin,in order to evaluate the effectiveness of traditional Chinese medicine treatment of the disease and sleep hour on the effect of the disease,and explore sleep rhythm and the correlation of the disease.Method:(1)Study on the clinical effect of Chinese Medicine on PCOS:Patients who were diagnosed as PCOS in the department of gynecology of Jiangsu Province Hospital of Chinese Medicine from October 2018 to July 2019 were selected,which were consistent with the syndrome of kidney deficiency and phlegm pattern,aged 11-24,have no family planning for nearly 2 years.The 90 patients included in the study were divided into a treatment group and a control group,45 in each.The treatment group was given Wenshenhuatan recipe orally,while the control group was given metformin orally for 6 months as a course of treatment,together with guide of sleep,asking patients to fall asleep as early as possible(no later than 1:00 am)with 7 hours of sleep a day.Glucose and lipid metabolism(BMI?WHR?FPG?FINS?HOMA-IR),sex hormone levels(T?SHBG?E2?LH?FSH),AMH,TCM syndrome scores and liver and safety index were observed at the initial diagnosis and 6 months of treatment respectively.(2)Explore the effect of sleep time on the curative effect of PCOS:According to the actual sleep time of patients during the treatment period,the treatment group was divided into the"Haishi"(21:00?23:00,Beijing time)sleep group and the "Zishi"(23:00?01:00,Beijing time)sleep group.The patients in the control group were divided into two groups:"Haishi" sleep group and the "Zishi" sleep group as well.Results:(1)TCM syndrome score:Compared within the group,the TCM syndrome score of the treatment group and the control group was significantly improved(P<0.05).The TCM syndrome score of the treatment group and the control group were significantly improved(P<0.01).Compared with the control group,the treatment group was superior to the control group in improving the score of TCM syndrome in the patients who fell asleep in Haishi and Zishi periods(P<0.01).(2)The glucolipid metabolism:Compared within the group,the treatment group and control group all can effectively improve Haishi and Zishi sleep in patients with BMI and WHR levels(P<0.05),for the traditional Chinese medicine therapy,HaiShi sleep can make its in the FPG,FINS,and HOMA-IR get extra benefit(Zishi sleep P>0.05,HaiShi sleep P<0.01),for the western medicine treatment,HaiShi sleep can make its WHR,BMI,FINS,and better improve HOMA-IR(Zishi sleep P<0.05,HaiShi sleep P<0.01);Compared between groups,the two groups had similar effect in improving the glucose and lipid metabolism in the patients(P>0.05).(3)The sex hormone levels:Compared within group,treatment group can significantly reduce the HaiShi sleep treatment group patients T,LH/FSH and AMH level(P<0.01),lower levels of LH who fall asleep in HaiShi(P<0.05),can significantly improve the Zishi fall asleep treatment group patients with LH,AMH and SHBG levels(P<0.01),improve the Zishi sleep treatment group patients with LH/FSH levels(P<0.05);Compared within the control group,the T level of the patients in the control group was significantly reduced(P<0.05 for those who fell asleep in Haishi,and P<0.01 for those who fell asleep in Zishi).There was no significant difference in the levels of sex hormones between the two groups after treatment for those who fell asleep in Zishi or in Haishi(P>0.05).(4)Menstrual effect:Sleeping in Haishi can effectively improve the effective rate of TCM and western medicine in treating this disease,and the effect is statistically significant(P<0.05).The effective rates of the two groups were similar,and the difference was not statistically significant(P>0.05).Conclusion:(1)Chinese and western medicine treatment of PCOS is safe and effective:For patients with the same sleeping time,the overall effective rate of wenshenhuatan prescription in improving menstrual efficacy of IR-PCOS patients with peri-adolescent kidney deficiency and damp phlegm is equivalent to metformin;The improvement of TCM syndrome score in patients with Hai and Zi shi sleep was superior to that in the metformin treatment group.Chinese and western medicine is safe and worthy of clinical promotion.(2)Influence of sleeping time on the therapeutic effect of traditional Chinese medicine:Compared with sleeping in Zishi,Haishi can enhance the therapeutic effect of wenshenhuatan recipe in improving the treatment efficiency,TCM syndrome score and glucose and lipid metabolism of patients.Therefore,it is recommended that all patients receiving TCM should sleep in the middle of the month to increase the therapeutic effect.(3)Influence of sleeping time on the therapeutic effect of western medicine:Compared with Zishi,Haishi can enhance the therapeutic effect of metformin in improving the effective rate of treatment and the level of glucose and lipid metabolism in patients.It is recommended that patients receiving western medicine,especially those with significant dysregulation of glucose and lipid metabolism,should fall asleep in Haishi to increase the curative effect of drug therapy.