Clinical Observation Of Xuekeshu Group Prescription In Treating Blood Stasis Syndrome Of Malignant Hematological Disease

Objective:In this study,the effects of Xuekeshu prescription on blood rheology test,blood coagulation function,platelet aggregation function,and TCM syndrome score of patients with malignant blood disease and blood stasis syndrome were observed.The clinical effect of the syndrome is to further deepen the research on the blood stasis syndrome of malignant blood disease,and provide a basis for its clinical improvement of blood stasis.Methods:From March 2018 to February 2020,a total of 40 patients with malignant blood disease and blood stasis syndrome that met the inclusion criteria were treated in the outpatient department and inpatients of the Hematology Department of XXX Hospital.They were divided into a traditional Chinese and western medicine treatment group and a western medicine treatment by random number table method.Group,20 cases in each group.The western medicine treatment group was given the conventional regimen of western medicine for all related diseases,and the integrated traditional Chinese and western medicine treatment group was added with the Xuekeshu group prescription on the basis of conventional western medicine treatment.Western medicines in both groups were excluded from anticoagulant,thrombolytic and antiplatelet aggregation drugs,such as low molecular weight heparin,warfarin,aspirin,etc.The observation period was 12 weeks.Hemorheology,coagulation function,platelet aggregation function,TCM syndrome score,blood routine,liver and kidney function were recorded before and after treatment in the two groups.After the data collection was completed,the SPSS22.0 software statistical system was used for analysis and comparison.Result:(1)Before treatment,there was no difference between the two groups in terms of gender,age and other physiological baselines(P>0.05);laboratory tests(whole blood reduced viscosity high cut,whole blood reduced viscosity low cut,plasma viscosity,red blood cell aggregation index,PT,APTT,FIB,DD,and platelet aggregation ratio)were not different(P>0.05);TCM syndrome scores were not different(P>0.05).The two groups of data can be compared and analyzed.(2)Hemorheology:The two groups of whole blood reduced viscosity high cut,the whole blood reduced viscosity low cut,and plasma viscosity values were lower than before treatment.The two groups of whole blood reduced viscosity high cut and low cut values were compared after treatment,P=0.00<0.01,there is a significant statistical difference between the two groups,indicating that the integrated Chinese and Western medicine group has a significant advantage in reducing the reduction of whole blood viscosity.Comparison of plasma viscosity values between the two groups after treatment,P=0.03<0.05,there is a significant statistical difference between the two groups,indicating that the combination of traditional Chinese medicine and western medicine has an obvious advantage over the western medicine group in reducing plasma viscosity.The comparison of the red blood cell aggregation index values between the two groups after treatment,P=0.588>0.05,there was no significant difference between the two groups.(3)Coagulation function:The PT and APTT values of the two groups were higher than before treatment and were basically within the normal range.The combined TCM and western medicine group was slightly higher than the western medicine group.The comparison of PT values after treatment between the two groups was P=0.039<0.05,both groups.There are significant statistical differences.It shows that the effect of prolonging the PT value of the TCM and WM group is significantly better than that of the WM group;the comparison of APTT values between the two groups after treatment,the comparison between groups,P=0.170>0.05,there is no significant difference between the two groups.The FIB and D-D values of the two groups decreased compared with the previous ones,and the P values were 0.588 and 0.388,respectively,and P>0.05.There was no significant statistical difference,indicating that the combination of traditional Chinese medicine and western medicine has the same effect as the western medicine group in extending APTT and reducing FIB and DD values.(4)Platelet aggregation ratio:The platelet aggregation ratio of both groups decreased after treatment compared with that before treatment.The comparison of platelet aggregation ratio between the two groups after treatment,P=0.327>0.05,there was no significant difference between the two groups.There was no significant difference in the efficacy of the aggregation ratio.(5)Symptoms of traditional Chinese medicine:The scores of the combined TCM and western medicine group were significantly lower than those of the western medicine group after treatment,P=0.001<0.01,there was a significant statistical difference.Comparison of the efficacy evaluation of TCM syndromes between the two groups before and after treatment,P=0.019<0.05,there was a significant statistical difference.It is suggested that the integrated Chinese and western medicine group can comprehensively improve the clinical symptoms of patients with malignant blood disease and blood stasis syndrome.Conclusion:Xuekeshu group prescription has exact clinical effect,which can obviously improve the symptoms of blood stasis in patients with malignant blood disease,improve the state of high blood coagulation and high viscosity,and has good safety without obvious risk of bleeding.The prognosis and outcome are quite helpful and have high clinical value.