| Objective:A randomized controlled trial was conducted to observe the clinical efficacy,clinical feasibility and safety of cirrhosis ascites no.1 recipe(self-made recipe)in the treatment of liver and spleen blood stasis type drum swelling in patients with liver and spleen blood stasis type drum swelling,so as to provide more ideas for the treatmen of liver and spleen blood stasis type drum swelling.Methods:In this study,a total of 60 patients(meeting the relevant inclusion criteria)were included,and they were randomly divided into treatment group(cirrhotic ascites no.1 + basic treatment group)and control group(basic treatment group)(refer to appendix2),with 30 patients in each group.Before treatment,there was no significant difference between the two groups in the basic data such as age,gender,course of disease,TCM syndrome score,abdominal moisture degree and liver function classification,so the two groups were comparable.The treatment group: liver cirrhosis ascites 1 square(2 times/day,oral,100 ml(1 bag)/time +foundation treatment,foundation treatment:(mild: moderate: 100mg/day of oral spironolactone spironolactone 100 mg + cefuroxime Sammy 40 mg/day of severe: spironolactone 100 mg + cefuroxime Sammy40 mg/day + 5,1 abdominal puncture in the morning on an empty stomach)treatment,the control group given basic treatment;Treatment course: 8 weeks;To observe the improvement of patients' clinical symptoms before and after treatment,SPSS 23.0statistical software was used to analyze relevant data,and conclusions were drawn based on the results of statistical analysis.Results:During the treatment,the basic vital signs(body temperature,heart rate,etc.),electrocardiogram and renal function of the patients were monitored,and no obvious adverse reactions were observed in the treatment group.In the control group,there were6 cases of fatigue abdominal distension and 2 cases of diarrhea during the treatment.After the relevant clinical efficacy indicators were analyzed and treated,the following results were obtained:(1)comparability analysis of the two groups before treatment was conducted,and the two groups were comparable in gender,age,TCM syndrome score and child-pugh score: P>0.05 no statistical difference was found,so the two groups were comparable.(2)The score of TCM symptoms in the treatment group was significantly lower than that in the control group: #P=0.007<0.01-the difference was statistically significant,indicating that cirrhotic ascites could significantly reduce the score of TCM symptoms and improve the symptoms of TCM,and the efficacy was better than that in the control group.(3)Through the comparison of the efficacy of TCM syndromes,the effective rates of the treatment group and the control group were 86.66% and 70.00%,respectively.P < 0.05 there was a statistical difference between the two groups,indicating that in the efficacy of TCM syndromes,cirrhotic ascites prescription was better than the control group.(4)Through the comparison of the overall clinical efficacy after treatment: the effective rates of the treatment group and the control group were 76.67% and 63.33%,respectively.P < 0.05 there was a statistical difference between the two groups,indicating that cirrhotic ascites prescription was superior to the control group in terms of overall clinical efficacy.(5)Through the treatment of abdominal water degree,abdominal circumference,24 h urine volume and body weight after the comparison: P<0.05 the treatment group and the control group had a statistically significant difference,indicating that the treatment of cirrhotic ascites prescription regression of ascites is better than the control group.(6)Through the comparison of child-pugh grade score,ALT,and AST of liver function after treatment,it is concluded that P<0.05-the difference between the treatment group and the control group is statistically significant,indicating that the curative effect of cirrhotic ascites prescription to improve the liver function of patients is better than the control group.(7)The comparison between the two groups before and after treatment showed that: *P=0.073>0.05,#P=0.081>0.05 portal vein diameter,spleen thickness were not significantly different,indicating that the treatment group and the control group were not significantly effective in alleviating portal vein hypertension and reducing spleen thickness.Conclusion:Cirrhotic ascites no.1 can effectively treat the liver and spleen blood stasis type bulging.According to the observation,the safety and therapeutic effect of this prescription are good,and no obvious adverse reactions have been observed in the patients.Cavity puncture in the morning on an empty stomach)for treatment,the control group gave basic treatment;Treatment course:8 weeks;To observe the improvement of patients' clinical symptoms before and after treatment,SPSS 23.0 statistical software was used to analyze relevant data,and conclusions were drawn based on the results of statistical analysis. |
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