Clinical Observation Of Zhengyan Decoction In The Treatment Of Wind-phlegm Resistance Facial Neuritis

Objective:Using the experienced prescription Zhengyan Decoction by Jiao Shude for the treatment of wind-phlegm resistance facial paralysis,to observe the clinical therapeutic effect of science,based on the related clinical data to evaluate curative effect of comparative analysis,to explore the action mechanism of Zhengyan Decoction,confirm the effectiveness of Zhengyan Decoction in the treatment of wind-phlegm resistance facial paralysis,to provide ideas for the future treatment of facial paralysis.Methods:1.General data:Patients with facial paralysis who were hospitalized in Huangpi district hospital of traditional Chinese medicine from June,2018 to December,2019 were collected.A total of 60 patients who met the western diagnostic criteria for facial paralysis and had the syndrome differentiation of wind-phlegm resistance the meridian were screened.They were randomly divided into the experimental group and the control group according to the simple Numbers,with 30 patients in each group.2.Treatment method:The control group was treated with western medicine clinical routine treatment:(1)hormone treatment of prednisone tablets orally,30mg/d,morning meal,continuous treatment for 7 days,8-14 days according to the changes in the score of the disease dose gradually reduced and stopped,a total of 14 days;(2)Antiviral therapy: 0.9% sodium chloride solution 250mL+ acyclovirinjection 1g intravenous drip once a day for 7 days;(3)Neurotrophic vitamin B1 injection 100mg and mecobalamin injection 0.5mg,intramuscular injection,once a day for 14 days,after 14 days changed to mecobalamin tablets oral,0.5mg each time,three times a day,oral for 2 weeks;(4)Improve circulation by 0.9% sodium chloride solution 250 mL + troxerutin 0.4g,intravenous drip,once a day,continuous use for 14 days;The treatment group was treated with traditional western medicine combined with Zhengyan Decoction : radix saposhnikoviae9 g,safflower 10 g,Schizonepeta 9g,scorpion 6g,uncaria 20 g,peach kernel10 g,vinegar turtle 12 g,rhizoma typhon 6g,angelica 10 g,gegen 12 g,water decoction,150 ml each time,three times a day,1 dose per day,each time after taking 7 doses according to the symptoms.2 weeks was one course of treatment,2courses in total,4 weeks in total.Both the control group and the experimental group received 2 courses of treatment,and were followed up for 1 month.3.Effect judgment:To observe the changes of patients in the control group and the treatment group at the time of admission,2 weeks after treatment,4 weeks after treatment,and 1 month of follow-up,including the scores of the house-brackmann scale,the therapeutic effect standard of TCM symptoms of facial paralysis(the self-healthy side control score of facial paralysis),and the facial disability index FDI(divided into FDIP score of physical function and FDIS score of social life function).Recording the above two groups of indicator data,and SPSS19.0 statistical software was used to process and analyze the recorded data,and the statistical analysis results of clinical efficacy index and clinical safety index of the two groups of data were respectively compared,to draw relevant conclusions.Results :A total of 58 cases were finally included in this clinical observation,among which 1 case fell off in the treatment group and 1 case was removed from the control group,and no experimental cases were suspended.(1)At the time ofadmission,there was no statistical difference between the two groups in the general data such as age,gender,weight,affected side,onset time,house-brackmann scale score,TCM symptom efficacy standard of facial paralysis,and facial disability index FDI(P>0.05),indicating that the data of the two groups were comparable;(2)After one course of treatment,the score of the house-brackmann scale,the therapeutic standard of TCM symptoms of facial paralysis,and the index of facial disability FDI in the two groups were improved compared with those at the time of admission,among which the therapeutic effect of the treatment group was better than that of the control group(P<0.05).The total effective rate of the treatment group was 86.21%,and that of the control group was 79.31%;(3)After 2 courses of treatment,the total effective rate was93.10% in the treatment group and 89.66% in the control group;(4)During the follow-up for 1 month,the improvement of patients in the treatment group in terms of house-brackmann scale score,TCM symptom efficacy standard of facial paralysis,and facial disability index FDI was better than that in the control group(P<0.05);(5)In the course of clinical observation,no obvious adverse reactions were observed in the two groups,and the conventional safety indexes were within the normal range,indicating that zhengyan decoction was safe in clinical use.Conclusion:Using Zhengyan Decoction combined with western medicine for treating wind-phlegm resistance facial paralysis than simply use western medicine clinical routine treatment,can more effectively improve the clinical symptoms,shortening the period of clinical treatment,and treatment period found no obvious adverse reactions and side effects,the safety and effectiveness of zhengyan decoction have been verified to some extent,and it is suitable for clinical use.