| Objective:To observe the clinical effect of Modified Dioscorea Pills on the cognitive function changes of Alzheimer's disease(AD)patients after treatment and on peripheral blood interleukin-6(IL-6),The effects of signal transducer and activator of transcription(STAT3),C-reactive protein(CRP),and Apoliporotei-A1(APO-A1)expression.Methods:1.In the first comprehensive evaluation of the elderly,Alzheimer's disease patients who met the criteria were included,and a randomized controlled research method was used to randomly divide 40 patients who met the criteria into two groups,namely the senile dementia control group and the senile dementia Chinese medicine group.At the same time,the hospitalized patients who met the normal cognitive function at the time of evaluation were included in the normal group.2.In clinical observation,the three groups of patients continue to treat the primary disease,the senile dementia control group is given basic treatment for dementia(cognitive rehabilitationtraining),and the senile dementia Chinese medicine group is given basic treatment for dementia and addition and subtraction of Dioscorea(concentrated soup,15 ml each time,taken twice a day)intervention,each group was observed for 12 weeks,divided into before treatment(the first comprehensive evaluation of the elderly),after treatment(the comprehensive evaluation of the elderly again after 12 weeks interval)3.Mini-Mental State Examination(MMSE)and Montreal Cognitive Assessment(MoCA)were performed on the three groups of patients before treatment(0 weeks)and after treatment(after 12 weeks).,Activity of Daily Living Scale(ADL),Pittsburgh sleep quality index(PSQI)and Alzheimer's disease syndrome scale(Pattern and Element of Syndrome of Alzheimer's disease,AD-PES-11),and the peripheral blood IL-6,STAT3,CRP,APOA1 indicators measured in the clinic as the clinical observation indicators of this study,a total of 12 weeks of observation,the data collected using Spss 26.0 The software performs comprehensive statistical analysis,and simultaneously observes and records the adverse reactions and safety indicators of patients with senile dementia in the traditional Chinese medicine group after intervention of traditional Chinese medicine.Results:1.Number of cases included and final resultsA total of 40 patients who met the AD inclusion criteria were included in this study.They were divided into two groups using a randomized and controlled method.Each group had 20 patients,and a total of 7 patients were dropped.There were 3 cases of senile dementia control group and 4 cases of senile dementia Chinesemedicine group.There were 33 AD patients who finally completed the study,with an overall dropout rate of 17.5%;normal group(hospital patients with normal cognitive function)There was no shedding,and finally 21 patients with normal cognitive function completed this clinical observation.2.General situationThere was no significant difference between the three groups in terms of gender,age,education level,and body mass index(BMI)(P> 0.05).All three groups are elderly patients,and there are more women than men.3.Mini Mental State Scale(MMSE)The scores of the three groups of patients before and after treatment were P> 0.05 in the normal group,P <0.05 in the senile dementia control group,and P <0.05 in the traditional Chinese medicine group in the senile dementia;the two groups were compared in pairs,the normal group and the elderly Dementia control group P <0.01,normal group and senile dementia Chinese medicine group P <0.01,senile dementia control group and senile dementia Chinese medicine group P <0.01.The results suggest that there is no significant difference in the MMSE scale score of the normal group after 12 weeks.The MMSE scale score of the senile dementia control group decreases after 12 weeks,and the MMSE scale score of the Alzheimer's disease Chinese medicine group increases after 12 weeks.It showed that the MMSE scale score of AD patients improved after12 weeks of intervention with Jiamin Shuhuan Pills,which further improved the patients' cognitive function.4.Montreal Cognitive Assessment Scale(MoCA)The scores of the three groups of patients before and after treatment were P> 0.05 in the normal group,P <0.05 in the senile dementia control group,and P <0.05 in the traditional Chinese medicine group in senile dementia.Dementia control group P <0.01,normal group and senile dementia Chinese medicine group P <0.01,senile dementia control group and senile dementia Chinese medicine group P <0.05.The results indicated that there was no significant difference in the MoCA scale scores in the normal group after 12 weeks.The MoCA scale scores in the senile dementia control group decreased after 12 weeks,and the MoCA scale scores in the senile dementia Chinese medicine group increased after 12 weeks.This indicated that the MoCA scale scores of AD patients improved after12 weeks of intervention with Modified Dioscorea Pills,which further improved the patients' cognitive function.5.Daily Life Ability Scale(ADL)The scores of the three groups of patients before and after treatment were P> 0.05 in the normal group,P <0.01 in the senile dementia control group,and P <0.01 in the senile dementia Chinese medicine group;the three groups of patients were compared two by two after treatment.Dementia control group P <0.01,normal group and senile dementia Chinese medicine group P <0.01,senile dementia control group and senile dementia Chinese medicine group P <0.05.The results suggest that there is no significant difference in the ADL scale score in the normal group after 12 weeks.The ADL scale score in the senile dementia control group increases after 12 weeks,and the ADL scale score in the senile dementia Chinese medicine group decreases after 12 weeks.It showed that the ADL scale score of AD patients improved after 12 weeks of intervention withJiashushuwan pills,which further improved the patients' daily life ability.6.Pittsburgh Sleep Quality Index(PSQI)The scores of the three groups of patients before and after treatment were P> 0.05 in the normal group,P <0.01 in the senile dementia control group,and P <0.01 in the senile dementia Chinese medicine group;the three groups of patients were compared in pairs,the normal group and the elderly Dementia control group P> 0.05,normal group and senile dementia Chinese medicine group P <0.01,senile dementia control group and senile dementia Chinese medicine group P <0.01.The results suggest that there is no significant difference in the PSQI score of the normal group after 12 weeks.The PSQI score of the senile dementia control group increases after12 weeks,and the PSQI score of the senile dementia Chinese medicine group decreases after 12 weeks;After 12 weeks,the PSQI score of AD patients has improved,thereby further improving the sleep quality of patients.7.TCM syndrome scoreNamely the Alzheimer's Disease Syndrome Element Scale(AD-PES-11),the scores of the three groups of patients before and after treatment were compared,the normal group P> 0.05,the senile dementia control group P <0.01,the traditional Chinese medicine Group P <0.01;three groups of patients were compared two by two after treatment,normal group and senile dementia control group P<0.01,normal group and senile dementia Chinese medicine group P<0.01,senile dementia control group and senile dementia Chinese medicine group P <0.05.The results suggest that there is no significant difference in the TCM syndrome scores in the normalgroup after 12 weeks.The TCM syndrome score in the senile dementia control group increases after 12 weeks,and the TCM syndrome score in the senile dementia Chinese medicine group decreases after 12 weeks.It showed that the TCM syndrome scores of AD patients improved after 12 weeks of intervention with Jiajianshuhuanwan,which further explained that Jiajianshuhuanwan could improve the clinical symptoms of patients.8.Interleukin-6(IL-6)The scores of the three groups of patients before and after treatment were P> 0.05 in the normal group,P <0.01 in the senile dementia control group,and P <0.01 in the senile dementia Chinese medicine group;the three groups of patients were compared two by two after treatment,the normal group and the elderly Dementia control group P <0.01,normal group and senile dementia Chinese medicine group P <0.01,senile dementia control group and senile dementia Chinese medicine group P <0.01.The results suggest that there is no significant difference in serum IL-6 after 12 weeks in the normal group.The serum IL-6 level in the senile dementia control group increased after 12 weeks,and the serum IL-6 level in the senile dementia Chinese medicine group after 12 weeks.Decreased;it indicates that the serum IL-6 of AD patients has improved after 12 weeks of intervention with Modified Dioscorea Pills.9.Signaling and Transcription Activating Protein 3(STAT3)The scores of the three groups of patients before and after treatment were P> 0.05 in the normal group,P <0.01 in the senile dementia control group,and P <0.01 in the senile dementia Chinese medicine group;the three groups of patients were compared two bytwo after treatment,the normal group and the elderly Dementia control group P <0.01,normal group and senile dementia Chinese medicine group P <0.01,senile dementia control group and senile dementia Chinese medicine group P <0.01.The results suggest that there is no significant difference in serum STAT3 after 12 weeks in normal group.Serum STAT3 level in senile dementia control group increases after 12 weeks,and serum STAT3 level in senile dementia Chinese medicine group decreases after 12 weeks;Serum STAT3 in AD patients improved after 12 weeks of pill intervention.10.C-reactive protein(CRP)The scores of the three groups of patients before and after treatment were P> 0.05 in the normal group,P <0.01 in the senile dementia control group,and P <0.01 in the senile dementia Chinese medicine group;the three groups of patients were compared two by two after treatment.Dementia control group P <0.05,normal group and senile dementia Chinese medicine group P> 0.05,senile dementia control group and senile dementia Chinese medicine group P <0.05.The results suggest that there is no significant difference in serum CRP in the normal group after 12 weeks.The serum CRP level in the senile dementia control group increases after 12 weeks,and the serum CRP level in the senile dementia Chinese medicine group decreases after 12 weeks.After 12 weeks of pill intervention,the serum CRP level of AD patients improved.11.Apolipoprotein A1(APO-A1)The scores of the three groups of patients before and after treatment were P> 0.05 in the normal group,P <0.01 in the senile dementia control group,and P <0.01 in the senile dementia Chinese medicine group;the three groups of patients were compared two bytwo after treatment.Dementia control group P <0.01,normal group and senile dementia Chinese medicine group P> 0.05,senile dementia control group and senile dementia Chinese medicine group P <0.01.The results indicated that there was no significant difference in serum APO-A1 in normal group after 12 weeks.Serum APO-A1 level in senile dementia control group decreased after 12 weeks,and serum APO-A1 level in senile dementia Chinese medicine group after 12 weeks Increase;it indicates that the serum APO-A1 level of AD patients has improved after 12 weeks of intervention with Modified Dioscorea Pills.12.Safety evaluationDuring the study period,the vital signs of the three groups of patients were stable;there was no obvious discomfort in the Alzheimer's disease Chinese medicine group;there were no significant changes in blood routine,liver and kidney function,electrolytes,electrocardiogram,and chest radiographs before and after treatment.Conclusion:In the clinical observation of the treatment of patients with Alzheimer's disease,Jiashushuwan not only increased the MMSE and MoCA scores,but also reduced the ADL,PSQI scores and TCM syndrome scores,and at the same time reduced the serum inflammation indicators IL-6,STAT3 and CRP The serum protective index APOA1 has increased compared with before;it indicates that the addition and subtraction of Shuhuan Wan can improve the daily life ability and cognitive function of AD patients,and its mechanism may be related to the regulation of the expression of IL-6 / STAT3 signaling pathway,thereby inhibiting AD patients.Neuronal cell apoptosis;and may be related to regulating the expression of serum CRP,thereby reducing the neuronal cytotoxicity of AD patients and inhibiting neuronal cell apoptosis;may be related to regulating the expression level of serum APOA1,thereby inhibiting amyloid aggregation and attenuating nerves Cytotoxicity,blocking neuronal damage and other anti-AD effects;the Alzheimer's disease Chinese medicine group has no obvious adverse drug reactions within 12 weeks of Chinese medicine intervention,which is safe and reliable,and needs further research,promotion and application. |
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