| Objective:Mild Cognitive Impairment (Mild Cognitive Impairment, MCI) are recent international research on the medical profession, means between normal aging and dementia in a transitional stage between the cognitive impairment, preventive interventions are the best stage . 5 kinds of TCM, the spleen and kidney deficiency type with up to see. [1] the subject has developed Jianpi Bushen, Tianjing Yisui rule of law, group Dioscorea pill side addition and subtraction. Through the spleen and kidney deficiency type mild cognitive impairment Clinical Observation and Piracetam Capsule (piracetam) in control, to explore the mechanism of its efficacy for the drug lay the foundation for clinical application.Ways:1. The clinical data of all cases the Department in June 2007 January 2009 in Hubei Province and the Chinese medicine hospital neurology clinic patients were randomly divided into treatment group and control group, one of the treatment group 30 cases, 30 cases of the control group, divided into application Dioscorea flavored pills, capsules Piracetam (piracetam) in the treatment. Treatment for 2 months. The prohibition of taking the course of treatment other nootropic drugs, as well as traditional Chinese medicine tonics, blood-activating agent. Treatment group and control group in terms of age, gender, disease course and treatment of pre-TCM, Chinese medicine Hou integral evaluation of the main symptoms of the spirit of Scale Points, points, points of TCM syndrome and compared the distribution of blood flow changes on the basic balance, by statistical analysis, no significant difference ( p>0.05 ) , comparable.2. Drug use treatment group was given flavored pill side Dioscorea ( subsidiary from Hubei College of Traditional Chinese Medicine out-patient hospital pharmacies ) 6 each, 3 times a day. Control group with Piracetam Capsule (piracetam) 0.2g / tablets every 4, 3 times a day half an hour after meals with warm water delivery service, for taking 2 months for a course of treatment. The prohibition of taking the course of treatment other nootropic drugs, as well as traditional Chinese medicine tonics, blood-activating agent.3. The efficacy and safety of observation before and after treatment were observed in patients with mental state examination ( MMSE ) points, SF-36 health survey questionnaire (Chineseversion) score, symptom score of Chinese medicine, TCM Syndrome effects, and hemorheology changes in indicators for assessing efficacy. Before and after treatment for hematuria conventional manure, blood glucose, liver and kidney functions ( ALT,AST,BUN,Cr ),Detect ECG.4. The statistical methods used in mind the number of data x test, measurement treatment with t tests, the information used to enable Level Ridit test.Results:1. MMSE score comparison:. MMSE test used by the statistical analysis, two groups have the efficiency of the overall difference was not significant ( p>0.05 ). Description Modified Dioscorea pills and brain rehabilitation medicine capsules two to mild cognitive impairment have memory intelligent improve significantly promote the role of2. SF-36 health survey questionnaire (Chinese version) Points in patients with mild cognitive impairment compared the quality of life indicators point that there was some improvement, compared with pre-treatment differences were significant (P<0.05P<0.01)3. TCM Syndrome basic effects of the treatment group recovered 10 cases, 12 cases markedly effective in 5 cases, 3 cases, the total effective rate 88.76; control group, nine cases of the basic recovery, 13 cases markedly effective, effective six cases, two cases of invalid The total effective rate 83.96 . After statistical analysis, treatment group and control group differences in the total efficiency has no significant ( p> 0.05 ) . Description Modified Dioscorea pills and brain rehabilitation medicine capsules two mild cognitive impairment on both spleen and kidney deficiency syndrome have significant effect on4. TCM main symptoms after the treatment effects of two main symptoms of varying degrees of improvement. After statistical analysis, between the two groups no significant ( p>0.05). Description Modified Dioscorea pills and brain rehabilitation medicine capsules two mild cognitive impairment of the spleen and kidney deficiency of the two main symptoms have significant effect on improving.5. Change hemorrheology comparison: the two groups after treatment hemorrheology indicators have improved, by statistical analysis of difference between the two groups no significant ( p> 0.05 ) . Description Modified Dioscorea and brain rehabilitation pill capsules of the two drugs have markedly improved hemorrheology role.6. Adverse reactions and side effects: treatment group and control group in the clinical trial period, no significant adverse reactions and side effects. Two sets of laboratory test results of conventional three laboratory, liver and kidney function before and after treatment did not appear abnormal with treatment-related changes.Conclusion:Observation results show that addition and subtraction Dioscorea pill treatment group and brain rehabilitation capsule control group MMSE points at,SF-36 health survey questionnaire (Chinese version) Points, TCM Syndrome symptoms, Chinese medicine and hemorheology changes, by the Census and Statistics Analysis of study showed no significant difference. At the same time, addition and subtraction diosgenin treatment of mild cognitive impairment pill spleen and kidney deficiency type of clinical efficacy sure. Can improve patients with mild cognitive impairment symptoms, improve MMSE score, improve the quality of life, improving hemorheology, has good prospects for clinical application.
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