| Objective: This clinical observation is on the basis of pure western medicine treatment,and attentively leacom pill in the treatment of chronic heart failure,by comparing before and after treatment in patients with cardiac function classification,the quality of life score and TCM symptoms integral,NT-proBNP,hypersensitive c-reactive protein and left ventricular ejection fraction,6 minutes walk test,and were followed up for 6 months before the change of the hospitalization rate,explore heart leacom efficacy and safety of the pill in the treatment of chronic heart failure,and discussed from the aspects of theory of heart leacom pill and cure effect mechanism,provide new proprietary Chinese medicine preparations for treatment of chronic heart failure,broaden the treatment of chronic heart failure.Methods: Selection of shiyan city,hubei province Chinese medicine hospital in October 2018 ~ October 2019 admitted 72 cases of patients with chronic heart failure as the research object,the 36 cases were randomly divided into test group and control group 36 cases,including 3 control fall off,fall off group 2 people,then patients divided into two qi and Yin deficiency and blood stasis type(10 cases)and the qi and Yin deficiency and blood stasis type(24 cases).Control to conventional western medicine therapy(selective use of diuretics,tube expanding,digitalis,ACEI/ARB,beta blockers,and aldosterone antagonists,such as drugs,patients in the control group on the basis of plus leacom pill to treat attentively,heart leacom pill preparation for our r&d,taking method for 3 times per day,6 g each time,both groups of treatment 4 weeks in a row,observe the following indicators: cardiac function classification,the quality of life score and TCM symptoms integral,the NT-proBNP,hypersensitive c-reactive protein and left ventricular ejection fraction,6 minutes walk test,and were followed up for 6 months before hospitalization rates and safety indicators.SPSS26.0 statistical software package was used for analysis.Results: 1)there were no statistically significant differences among the three groups in gender,age,course of disease,cardiac function classification,combined basic diseases,quality of life score before treatment,TCM syndrome score,nt-probnp,hypersensitive c-reactive protein,left ventricular ejection fraction,6-minute walking test and other general information(P > 0.05).2)improvement of TCM symptom score after treatment in the three groups: > in qi-yin deficiency and blood stasis group and > control group in non-qi-yin deficiency and blood stasis group,the difference was statistically significant(P < 0.05).3)improvement degree of cardiac function after treatment in the three groups: > in the qi-yin deficiency and blood stasis group and the non-qi-yin deficiency and blood stasis group and the > control group,the difference was statistically significant(P < 0.05).4)after treatment,the level of nt-probnp in the three groups decreased compared with that before treatment,and the degree of decrease was as follows: > in the qi-yin deficiency and blood stasis group and the non-qi-yin deficiency and blood stasis group and the > control group,and the difference was statistically significant(P < 0.05).5)ejection fraction in the three groups increased after treatment,and the degree of improvement was as follows: > in the qi-yin deficiency and blood stasis group and the non-qi-yin deficiency and blood stasis group and the > control group,the difference was statistically significant(P < 0.05).6)the 6-minute walking distance of patients in the three groups increased after treatment compared with that before treatment,and the increase degree was as follows: > in the qi-yin deficiency and blood stasis group and the non-qi-yin deficiency and blood stasis group and the > control group,the difference was statistically significant(P < 0.05).7)the level of hypersensitive c-reactive protein in the three groups decreased after treatment compared with that before treatment,and the degree of decrease was as follows: > in the qi-yin deficiency and blood stasis group and the non-qi-yin deficiency and blood stasis group and the > control group,and the difference was statistically significant(P < 0.05).8)after treatment,the quality of life score of patients in the three groups decreased before treatment,and the degree of decrease was as follows: > in the qi-yin deficiency and blood stasis group and the non-qi-yin deficiency and blood stasis group and the > control group,and the difference was statistically significant(P < 0.05).9)after treatment,the re-hospitalization rate of the three groups was as follows: qi-yin deficiency and blood stasis group < non-qi-yin deficiency and blood stasis group < control group.10)there was no abnormal change in the safety indexes of the three groups after treatment,and no serious adverse reactions occurred during the experiment.Conclusion: Heart leacom pill in the treatment of chronic heart failure with good effect,for qi and Yin deficiency and blood stasis type effect is better,can improve the patients' clinical symptoms and cardiac function,reduce the NT-proBNP and hypersensitive c-reactive protein levels,improve cardiac ejection fraction and 6 min walking distance test,reduce hospitalization rates again,improve the quality of life,and no obvious adverse reactions. |
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