Analysis Of The Role Of Platelet Count/spleen Maximum Diameter Ratio In Predicting Late Recurrence Of Hepatocellular Carcinoma After Hepatectomy

ObjectiveTo study the role of PSR in predicting late recurrence of hepatocellular carcinoma after hepatectomy.MethodsA retrospective analysis was made on the clinical date of 119 patients who underwent liver resection and were pathologically confirmed as HCC between January 1,2012 to December 31,2016 at the first affiliated hospital of Zhengzhou University.The clinical data before surgery and pathological data were collected,then postoperative follow-up was made.kaplan-meier method and Cox proportional hazard regression(Cox)were used to analyze recurrence-free survival rates and the risk factors for late recurrence of HCC after surgery.ResultsThe results of univariate analysis showed that the late recurrence of patients with HCC after surgical resection was statistically significant in relation to PSR,serum AFP level and the maximum diameter of the spleen(P<0.05),but not statistically significant in relation to age,gender,serum ALT level,the number of tumor,portal vein thrombus,maximum diameter of tumor,HBV or HCV infection,and the location of tumor.The results of multivariate analysis showed that PSR?909(HR=3.142,95.0%CI 1.194-8.271,P=0.020)and AFP ? 400 ?g/L(HR=3.369,95.0%CI 1.225-9.261,P=0.019)were independent risk factors for late recurrence of HCC patients after surgical resection.Survival analysis shows recurrence-free survival rate of patients between PSR?909 and PSR>909 was significantly different(?2=30.747,P<0.001),and recurrence-free survival rate of group PSR?909 was lower than the other group.Conclusion1.PSR?909 and AFP?400 ?g/L are independent risk factors for late recurrence of HCC after surgical resection.Preoperative evaluation of PSR.can predict late recurrence of HCC to a certain extent.2.Maximum diameter of the spleen is a related factor for late recurrence of hepatocellular carcinoma after hepatectomy.