Clinical Study Of Inflammatory Factors For Chronic Glomerulonephritis(Kidney Deficiency And Blood Stasis Syndrome)with Caohua Fupen Granules

Objective: In this paper,through the clinical study of Caohua Fupen Granules in patients with chronic glomerulonephritis(kidney deficiency and blood stasis syndrome),the clinical efficacy of patients,24-hour urinary protein quantification,renal function(Scr,BUN),and changes of inflammatory factor IFN-?,IL-4,IL-10,Th1/Th2 in peripheral blood were observed and further explore its mechanism of action.Methods:The study selected 60 patients with chronic glomerulonephritis who met the requirements and were randomly divided into a control group and a treatment group,each with 30 cases.The control group was treated with Losartan Potassium Tablets;the treatment group was treated with Losartan Potassium Tablets + Caohua Fupen Granules,and both groups were treated for 8 weeks.Compare the clinical efficacy,24-hour urinary protein quantification,renal function(Scr,BUN),changes of IFN-?,IL-4,IL-10,Th1 / Th2 in peripheral blood before and after treatment,and record the occurrence of adverse reactions.Data were statistically analyzed with SPSS20.0 software.Results:(1)The clinical efficacy of patients in the control group and the treatment group were compared.After 8 weeks of treatment,the total clinical effective rate of the treatment group was 80.00%,which was significantly better than the control group of 53.33%.Compared with the control group,the total effective rate of the treatment group was significantly higher than the control Group,the difference was statistically significant(P <0.05).(2)Comparing the 24-hour urinary protein quantification of patients in the control group and the treatment group.The urinary protein of the two groups decreased significantly after 8 weeks of treatment.Compared with the control group,the urinary protein level in the treatment group was lower than that in the control group,the difference was statistically significant(P<0.05).(3)The renal function(Scr,BUN)of patients in the control group and the treatment group were compared.After 8 weeks of treatment,the creatinine and urea nitrogen of the two groups were significantly reduced.Compared with the control group,the blood creatinine and urea nitrogen of the treatment group were significantly lower than the control group,the difference was statistically significant(P <0.05).(4)The IFN-?,IL-4,IL-10,Th1/Th2 in peripheral blood of patients in the control group and the treatment group were compared.After 8 weeks of treatment,the levels of IFN-? and Thl/Th2 in the two groups were significantly reduced,compared with the control group,the IFN-?and Thl/Th2 values of the treatment group were lower than the control group,the difference was statistically significant(P<0.05);after 8 weeks of treatment,the levels of IL-4 and IL-10 were significantly higher than before treatment,compared with the control group,the IL-4 and IL-10 of the treatment group were higher than the control group,the difference was statistically significant(P<0.05).Conclusion:(1)Caohua Fupen Granules can improve the levels of inflammatory factors in peripheral blood of patients with chronic glomerulonephritis(kidney deficiency and blood stasis syndrome).(2)Caohua Fupen Granules can improve renal function in patients with chronic glomerulonephritis(kidney deficiency and blood stasis syndrome)by reducing urinary protein and reducing inflammatory response.(3)Caohua Fupen Granules can assist western medicine to improve the clinical effect of chronic glomerulonephritis(kidney deficiency and blood stasis syndrome),and provide theoretical basis and clinical guidance for the clinical application of integrated traditional Chinese and western medicine for chronic glomerulonephritis.