| Target:In this study,Gegen Qinlian Dispelling Turbidity Decoction was used to treat patients with type 2 diabetes mellitus(T2DM)combined with non-alcoholic fatty liver disease(NAFLD),and to observe its effect on the serum Omentin-1 and A-FABP level of the patients impersonally;to explore the possible mechanism of the treatment of the disease by Gegen Qinlian Dispelling Turbidity Decoction.Approaches:60 cases of patients with type 2 diabetes and non-alcoholic fatty liver admitted to the outpatient department and ward in the department of cadre endocrinology were(with liver stasis,spleen deficiency,phlegm turbidity),separated into: control group(30 cases,given basic treatment),treatment group(30 cases,given basic treatment and Gegen Qinlian Dispelling Turbidity Decoction plus or minus treatment)stochastically,after 12 weeks of drug treatment,to observe the TCM syndromes before and after treatment Points,general physical examination indicators,blood glucose related indicators,blood lipid related indicators,liver function indicators,liver B-ultrasound classification,fat factor(omentin-1,A-FABP)and other indicators,while monitoring safety indicators and using statistical methods to disposal and analyze the datas.The results :? TCM efficacy and syndrome score: the total effective rate in the treatment group was93.33%,which was higher than the 70.00% in the control group(P<0.05);the syndrome scores of the two groups were distinct compared to those before treatment(P<0.05);Comparing between the groups,there was a manifest difference in the efficacy of the treatment group(P<0.01).? General physical examination indicators: There were no manifest differences in BMI and WHR between the two groups of patients before treatment(P>0.05);? Blood glucose-related indicators: FPG,2h PG,Hb A1 C,FINS,and HOMA-IR levels of patients in the treatment group and the control group decreased after treatment,which were different from those before treatment(P<0.05).Comparing between groups,the curative effect of the treatment group were manifestly distinct(P<0.01).?Blood lipid-related indicators: The TC,TG,and LDL-C levels of patients in the treatment group and the control group decreased,and HDL-C levels increased,compared with those before treatment(P<0.05),after treatment.Comparison between groups,the treatment group's efficacy were significantly different(P<0.01).?Liver function-related indicators: After treatment,the levels of ALT,AST,and GGT in patients in the treatment group and the control group decreased(P<0.05),which were different from those before treatment(P<0.05).Comparing between groups,the curative effect of the treatment group There were significant differences(P<0.01).? Liver B-ultrasound classification:the liver B-mode ultrasound classification of patients in the treatment group was lower than before,and the difference was statistically significant(P<0.05).The difference in liver B-mode classification before and after treatment in the control group was not statistically significant(P>0.05).Comparing between the two groups,the two groups were statistically significant in reducing liver B ultrasound classification(P<0.05);? Adipokine: The levels of Omentin-1 increased and the levels of A-FABP decreased after treatment in patients in the treatment group and the control group(P<0.05);there were differences compared with before treatment(P<0.05),comparison between groups There was a significant difference in the efficacy of the treatment group(P<0.01).?During the treatment,no manifest adverse reactions occurred in both groups.Conclusion: Gegen Qinlian Dispelling Turbidity Decoction can reduce blood sugar and blood lipids,repair liver function,and can improve IR,liver B-ultrasound and TCM symptoms.Its mechanism may be related to correcting the inflammatory state of the prescription,reducing IR and so on,and the safety is good,the curative effect is positive. |
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