Gegen Qinlian Decoction And Sini Powder In The Treatment Of Damp-heat IBS-D Clinical Observation

Objective: To observe the clinical efficacy of gegenqinlian decoction and Sinisan in the treatment of damp-heat IBS-D,and to provide a new idea and method for the prevention and treatment of damp-heat IBS-D with traditional Chinese medicine.Methods : 50 patients with irritable bowel syndrome were divided into observation group(n=27)and control group(n=23)according to the random number table.The clinical efficacy of gegenqinlian decoction in the treatment of damp-heat IBS-D was evaluated by clinical symptom score(IBS-SSS scale),quality of life scale(IBS-QOL),efficacy index,TCM symptom score,changes of plasma IL-6 before and after treatment,expression of IL-6 before and after colonic mucosa treatment,recurrence rate and safety index,etc.Results :(1)The TCM symptom scores in the observation group decreased after treatment(P<0.05).After treatment,the scores of abdominal pain,diarrhea and anal flatulence in the observation group were lower than those in the control group(P<0.05),and there was no significant difference between the observation group and the control group(P>0.05).(2)The scores of IBS-SSS scale in treatment group and control group decreased significantly after treatment(P<0.01),while those in treatment group decreased significantly after treatment(P<0.05).(3)IBS-QOL scale each dimension after treatment and treatment before integral contrast significantly increased(P<0.01),which in anxiety,behavior disorders,body mind,health concerns,the interpersonal dimension,observation group after treatment higher scores than the control group significantly(P<0.05),in a picky about food,sex,social function dimensions,the observation group and control group after treatment integral has no obvious difference(P>0.05).(4)There was no significant difference in plasma IL-6 content between the two groups before treatment(P>0.05).After treatment,the plasma IL-6 content in both groups decreased significantly(P < 0.01).The decrease level of plasma IL-6 in the observation group was significantly better than that in the control group(P<0.01).(5)The expression of IL-6 gene was detected in the colonic mucosa of the patients in the observation group before treatment.After 8 weeks of treatment,the expression of IL-6 gene was not detected in most of the colonic mucosa of the patients,and the expression of IL-6 inflammatory factors was partially detected.However,due to its messy melting curve,the data was of little significance for reference.(6)After the treatment,the total effective rate of the observation group was96.30%.The total effective rate in the control group was 69.60%.The observation group was superior to the control group(P<0.05).(7)Follow-up was conducted 8 weeks after the end of treatment,and the recurrence rate of the observation group was 7.6%.The recurrence rate of the control group was 13.3%,and the difference between the two groups was not statistically significant(P>0.05).Conclusion:(1)Gegen Qinlian Decoction combined with Sinisan can reduce the expression of IL-6 in plasma of patients with Damp-heat IBS-D,which may be one of the targets of Gegen Qinlian Decoction combined with Sini Powder in the treatment of damp-heat IBS-D patients.(2)Gegenqinlian decoction and Sinisan powder are better than trimebutin maleate in clinical efficacy and improvement of symptoms of traditional Chinese medicine for patients with dampness-heat IBS-D,and better than trimebutin maleate in reducing IBS-SSS and IBS-QOL scale score,with high safety and good long-term efficacy,which is worthy of further promotion and application in clinical practice.