| Objective:The aim of this meta-analysis was to evaluate the Effects of ovarian endometriosis on clinical outcomes of infertility patients treated with in vitro fertilization-embryo transfer.Methods : Such databases as CNKI,Wanfang,China Biomedical Literature Database(CBM),Pubmed,Cochrane Library were searched from inception of each database until January,2020.No language restrictions were applied.All trials of ovarian endometriosis on clinical outcomes of infertility patients treated with in vitro fertilization-embryo transfer were included.and analyzed them in the RevMan Manager 5.3 software.Results:Ten RCTs or retrospective analysis were analyzed.(1)There were no signifcant diferences in clinical pregnancy rate between women who underwent surgery for endometriosis and those who did not [OR =1.04.,95% CI(0.79-1.35)](2)There were no signifcant diferences in FSH between women who underwent surgery for endometriosis and those who did not[mean difference =0.37.,95%CI(-2.27-3.01)](3)There were no signifcant diferences in E2 between women who underwent surgery for endometriosis and those who did not[mean difference =0.20.,95% CI(-0.76-1.17)](4)There were no signifcant diferences in AMH between women who underwent surgery for endometriosisand those who did not[mean difference =-0.63.,95% CI(-0.75-0.52)](5)There were no signifcant diferences in follicle count between women who underwent surgery for endometriosis and those who did not[mean difference =-1.90.,95%CI(-2.48--1.32)](6)There were no signifcant diferences in AFC between women who underwent surgery for endometriosis and those who did not[mean difference =-1.39.,95%CI(-1.80--0.97)].Conclusion:Current evidence suggests that women with endometrio sis-related infertility have similar cycle outcomes to other patients going through ART.Pre-cycle surgical management of endometriosis does not appear to be benefcial aside from achieving symptom relief,although heterogeneity amongst studies make data analysis challenging. |
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