Amplitude Of Low-frequency Of Frist-episode Drug-naive Schizophrenia And Unaffected Parents:a Resting-state Functional Magnetic Resonance Imaging Study

Objective:To explore the similarities and differences of low-frequency amplitude frist-episode drug-naive schizophrenia and there unaffected parents and normal controls,to study whether schizophrenia patients and their unaffected parents have common abnormal brain regions,providing a new basis for understanding the relationship between genetic and schizophrenia.Methods:We used 1.5T fMRI to assess the whole brain activity in the resting-state from twenty-nine patients(patient group)with frist-episode drug-naive schizophrenia which diagnosed by Diagnostic and Statistical Manual of Mental Disorders,Fourth Edition(DSM-?)and forty three non-affected biological fathers or mothers(parent group)and twenty-nine healthy controls(control group)use age as a covariate.Two experienced psychiatrists accessd schizophrenia patients and there unaffected parents positive and negative syndrome scale(PANSS)and mini-mental state examination(MMSE).For rs-fMRI data were preprocessed then useing the low-frequency amplitude as a comparison.Results:Compared with the healthy controls,the patient group showed significantly increased ALFF in the left inferior frontal triangle,bilateral frontal cortex,the left temporal cortex,and the left anterior cingulate cortex,decreased ALFF in the right heschl,left precuneus and the right postcentral.Compared with the healthy control group,decreased ALFF of the parental group in the left inferior frontal triangle.The patient group showed significantly increased ALFF left inferior frontal triangle and bilateral mid-frontal cortex compared with the healthy parent group.Conclusion:There are multiple brain dysfunctions in the frist-episode drug-naive schizophrenia patients and their unaffected parents at rest,which may be related to the genetic endophenotype of schizophrenia.