| Part I Reduced fraction Amplitude of Low-frequency Fluctuation and Facial emotion perception Impairment in first-episode Schizophrenia BACKGROUND: A possible explanation for severe impairment of social cognitive functions in schizophrenia may be general impairments in the aberrant face detection and processing of facial information.But the underlying neural mechanisms and its relationships with abnormal face emotion perception remain unknown.The aim of present study was to analysis the change of brain functional activity by using resting-state functional magnetic resonance imaging(R-fMRI)of fraction amplitude of low frequency fluctuation(fALFF)measurement technique,and research the correlations between the abnormal activities of brain region and facial emotion perception.METHODS: Fifty-five First-episode,treatment-na?ve patients with schizophrenia(FES)and twenty-seven healthy controls matched for age and gender underwent fMRI scans and facial emotion categorization(FEC).Aberrant intrinsic activities in FES were then correlated to facial emotion categorization performance.RESULTS: Compared to healthy controls,patients with FES showed decreased fALFF values in the bilateral postcentral gyrus,bilateral middle temporal gyrus,left superior frontal orbital,left precuneus,right superior temporal gyrus,right middle cingulum,left inferior occipital gyrus and left cuneus(p<0.01).In patients with FES,significant positively correlation between fALFF in left middle temporal gyrus and slope of FEC(r=0.303),and for the shift point of FEC,a significant positive correlation cluster emerged in the right rolandic operculum(r=0.424)and left frontal superior orbital(r=0.457).CONCLUSIONS: These associations between facial emotion categorization dysfunction and aberrant intrinsic activities,and clinical symptoms in FES patientsmay provide important insights into the neural mechanism of the schizophrenia.Part II Reduced Fractional Amplitude of low-Frequency Fluctuation and Cognitive Impairment in the First-episode Schizophrenia BACKGROUND: The fractional Amplitude of low-Frequency Fluctuation(f ALFF)can provide a specific method to measure brain spontaneous activity in terms of the blood oxygenation level-dependent(BOLD)signal.Lower f ALFF in schizophrenia has been reported,but the correlation between neurocognitive and reductions of f ALFF remain unclear.We aim to identify association between regional f ALFF and neurocognitive.Exploring the mechanism of abnormal brain activity in cognitive disorders of schizophrenia.METHODS: Resting-state f MRI data and neurocognitive test data were collected from first-episode schizophrenia patients(FES;n=47)and healthy controls(HC;n=30).Psychopathology ratings were obtained using Positive and Negative Syndrome Scale(PANSS)data.All participants underwent structural and functional MRI scan.For identify the association between the alteration of f ALFF and the cognitive data were using correlation analysis.RESULTS: Compared with controls,there are reduced f ALFF in the right precuneus,left calcarine,left lingual,right angular,right postcentral,right cuneus,left inferior occipital,right middle temporal gyrus of FES patients(p<0.01).And FES patients had poorer cognitive performance in most of the cognitive tests.The score of Digit span test performance was negatively associated with f ALFF in the right precuneus(r=-0.44).The card A correct of Stoop Color-word Test performance was positively associated with f ALFF in the left lingual(r=0.36).Trail Marking Test A performance was positively correlation with f ALFF in the right angular(r=0.39).Besides,the f ALFF in the left inferior occipital gyrus(r=0.42)and left calcarine(r=0.38)was positively correlation with the Semantic similarity test performance.CONCLUSIONS: Our findings indicate that smaller f ALFF in these brain regions were associated with poorer neurocognitive performance and provide some scientific evidences for the cognitive dysfunction mechanism of schizophrenia. |
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