Changes Of Sleep Structure And Its Influencing Factors In Patients With Acute Ischemic Stroke

Objective: To understand the changes of sleep structure and its influencing factors in patients with acute ischemic stroke.Methods: Patients with acute ischemic stroke hospitalized in the department of neurology of the 940 th hospital of the joint logistic support force of the people's liberation army(formerly lanzhou military region general hospital)from December 2017 to September2018 were collected,which met the diagnostic criteria revised by the fourth academic conference on cerebrovascular diseases of the Chinese medical association in 1995.A total of52 patients with acute ischemic stroke were collected in this study.During the period of admission,polysomnography was improved to analyze the sleep parameters of the enrolled patients.Results:(1)The age of patients without obstructive sleep apnea after stroke was significantly lower than that of patients with obstructive sleep apnea,central sleep apnea and mixed sleep apnea(P<0.01),with significant statistical difference.(2)The hemispheric group,the left group,the right group,the non-thalamic group,and the thalamic group all had lower sleep efficiency than the norm,with statistically significant differences(P < 0.05).Compared with the normal mode,the hemispheric group,brainstem group,left group,right group,non-thalamic group,and thalamic group,the number of nocturnal arousal increased,the proportion of S1 and S2 increased,the proportion of S3 and REM decreased,and the AHI index increased significantly(P < 0.05).(3)Compared with the hemispheric and brainstem groups,the REM latency period in the multiple stroke group was significantly prolonged(P<0.05).(4)After stroke,obstructive sleep apnea group,central sleep apnea group,and mixed sleep apnea group showed decreased sleep efficiency,increased number of awakenances,and increased proportion of stage S1,with statistically significant differences(P< 0.05).Compared with the norm,the proportions of S2 stage and REM stage in the four groups without sleep apnea,obstructive sleep apnea,central sleep apnea and mixed sleep apnea after stroke were all reduced,with statistically significant differences(P < 0.05).Conclusions:(1)Sleep parameters of patients with acute ischemic stroke are prone to change,including sleep efficiency,number of awakenances,sleep structure and respiratoryevent parameters during sleep.(2)Changes in sleep parameters after stroke may be related to stroke events,but it is not clear whether there is a correlation between sleep parameters and specific sites of stroke.(3)Patients with acute cerebral stroke are prone to sleep disorders,and patients with cerebral stem stroke and right cerebral hemisphere stroke are more prone to sleep disorders.Therefore,clinical medical personnel should pay more attention to early detection and treatment to improve the prognosis and quality of life of patients with sleep disorders after stroke.