Clinical Observation On The Treatment Of Chronic Glomerulonephritis By Corn Stigma Mixture

PurposeThis study evaluated the efficacy and safety of Corn Stiga mixture by observing t he changes of 24-hour urine protein quantification,TCM syndrome score and other la boratory tests before and after treatment of chronic glomerulonephritis with Qi Yin def iciency syndrome and dampness-heat.MethodsAccording to the principle of random control,73 cases of chronic glomerulonephr itis with Qi Yin deficiency syndrome and dampness-heat were randomly divided into observation group(37 cases)and control group(36 cases).The observation group rece ived basic treatment + Corn Stiga mixture,and the control group received basic treat ment + Benazepril,and the treatment cycle was 12 weeks.The changes of 24-hour ur ine protein quantification and TCM syndrome score before and after treatment were o bserved,and the clinical efficacy of the observation group and the control group were compared.Results1.A total of 73 samples were included,37 in the observation group and 36 in th e control group.One patient in the observation group withdrew from the experiment b ecause he could not tolerate the taste of medicine after taking traditional Chinese med icine.One patient in the control group could not take benazepril on time due to work demands.The above two patients were confirmed by telephone for many times,and finally were treated according to the shedding cases.In the final study,a total of 71 samples were completed,including 36 cases in the observation group and 35 cases in the control group,with a shedding rate of 2.74%.2.There were no statistically significant differences between the two groups in ge nder,age,course of disease,TCM syndrome score and laboratory indicators before tre atment(P>0.05),which was comparable.3.The urine protein quantification in the observation group was lower 24 hours a fter treatment than before treatment(P<0.05),and the TCM syndrome score was lower(P<0.05).In the control group,the urine protein content in the urine for 24 hours af ter treatment was lower than that before treatment(P<0.05),and the TCM syndrome s core was lower(P<0.05).4.The effective rates of chronic glomerulonephritis in the observation group and the control group were 88.89% and 60.00% respectively,with statistical difference bet ween the two groups(P<0.05).5.The total effective rate of TCM syndrome points in the observation group and the control group was 86.11% and 51.42%,respectively,and the therapeutic effects o f the two groups were significantly different(P<0.001).6.During the observation,no significant adverse reactions were observed in all th e patients,no significant abnormal changes were observed in laboratory indexes such as blood routine,urine routine,stool OB,liver and kidney function,electrolyte and electrocardiogram examination,and no statistically significant differences were observed before and after treatment(P>0.05).Conclusion1.Corn Stiga mixture can significantly reduce the quantitative level of 24-hour ur ine protein in patients with chronic glomerulonephritis of both deficiency of Qi Yin d eficiency syndrome and dampness-heat type.2.Corn Stiga mixture can significantly reduce the TCM syndrome points of patie nts with both deficiency of Qi Yin deficiency syndrome and dampness-heat chronic gl omerulonephritis.3.No obvious adverse reactions were found in the Corn Stiga mixture.