The Changes Of Serum FABP4 And Clinical Significance In Patients With Chronic Obstructive Pulmonary Disease

Objective:To observe the effect of adipocyte fatty acid-binding protein（FABP4）on comprehensive evaluation of the severity of chronic obstructive pulmonary disease（COPD）,and to analysis the correlations between FABP4 and other inflammatory markers,oxidative stress markers and lung function,providing new ideas for the assessment of COPD and the search for new therapeutic targets.Methods:A total of 55 patients with acute exacerbation of COPD（AECOPD）hospitalized in the respiratory department of our hospital from December 2017 to September 2018 were selected as AECOPD group.According to the times of acute exacerbation in the previous year,patients in AECOPD group were divided into the high-risk group and the low-risk group.According to patients’symptoms,signs and echocardiography,AECOPD patients were divided into the group with cor pulmonale and the group without cor pulmonale.In the same period,55 patients with chronic obstructive pulmonary disease（SCOPD）who admitted to the respiratory department of our hospital were selected as SCOPD group.42 healthy adults who underwent routine physical examination at the physical examination center of our hospital during the same period were selected as control group.All subjects’age,gender,body mass index,the times of acute exacerbation in the previous year and blood pressure were collected.Serum FABP4 and8-isoprostaglandin（8-iso-PG）levelsweremeasuredbyELISA.Triglycerides,total cholesterol,fasting blood glucose,percentage of neutral cells,percentage of lymphocytes and serum c-reactive protein and other experimental indicators of AECOPD group were recorded on the day of admission,and the neutrophil lymphocyte ratio（NLR）was calculated.Chest radiography,electrocardiogram,echocardiogram and lung function data were collected.Carry on the statistical analysis.Results:（1）There were no statistically significant differences in general clinical data between the AECOPD,SCOPD and control groups,including age,gender,body mass index,diastolic blood pressure,systolic blood pressure,triglyceride,total cholesterol and blood glucose levels.（2）Serum FABP4 and 8-iso-PG levels in the AECOPD group and SCOPD group were higher than those in control group,and the serum FABP4 and 8-iso-pg levels in the AECOPD group were higher than those in the SCOPD group,with statistically significant differences（P<0.05）.（3）The level of serum FABP4 in AECOPD group was positively correlated with serum c-reactive protein（P<0.05）,but not significantly correlated with NLR（P>0.05）.（4）FABP4 was positively correlated with 8-iso-PG in both AECOPD group and SCOPD group（P<0.05）.（5）Serum FABP4 levels in AECOPD group and SCOPD group were negatively correlated with FEV₁%pred（P<0.05）.（6）The level of FABP4 in peripheral blood of patients with high risk of acute exacerbation was significantly higher than that of patients with low risk of acute exacerbation in AECOPD group,and the difference was statistically significant（P<0.05）.（7）the level of FABP4 in peripheral blood of patients with cor pulmonale complicated with AECOPD was significantly higher than that of patients without cor pulmonale complicated with AECOPD,and the difference was statistically significant（P<0.05）.Conclusion:（1）FABP4 may be a potential biomarker for the response of COPD.（2）FABP4 may be associated with oxidative stress in COPD,and its specific mechanism needs to be further studied.（3）FABP4 can be used as a potential indicator for the comprehensive evaluation of the severity of COPD.（4）FABP4 has certain reference value in the diagnosis of COPD complicated with cor pulmonale.