Clinical Value Of Hs-cTnT And H-FABP For Early Heart Dysfunction Assessment In Patients With Acute Exacerbations Of Chronic Obstructive Pulmonary Disease

Objective To explore clinical value of hs-c Tn T and H-FABP to assess early heart dysfunction in patients with acute exacerbations of chronic obstructive pulmonary disease by comparing levels of hs-c Tn T and H-FABP before and after treatment.Methods 110 patients with clinician-diagnosed AECOPD have prospectively studied from December,2015 to June,2016.Among them,80 eligible patients were recruited,including thirty-five mild-to-moderate,forty-five severe-to-very severe AECOPD patients and forty participants as control group,and gathered the clinical data.Serum hs-c Tn T and H-FABP concentration were determined by electrochemiluminescence method and enzyme-linked immunosorbent assay,respectively.Pulmonary function,arterial blood gas,AST,LDH,CK,CKMB,c Tn I and myoglobin were evaluated in each subject.We compared general information and myocardial biomarkers among groups.At the same time,after having regular medical therapy in accordance with the GOLD2015 guidelines for the treatment of AECOPD patients,we measured the above indicators when the AECOPD patients in stable state again.Results There was a significantly higher levels of hs-c Tn T and H-FABP in AECOPD patients compared with the control group(P < 0.001).The levels of H-FABP were significantly decreased in mild-to-moderate AECOPD group after treatment(P<0.01),as hs-c Tn T were not(P>0.05).The levels of hs-c Tn T and H-FABP were significantly decreased in severe-to-very severe AECOPD group after treatment(P < 0.01).There was no significant difference in AST,LDH,CK,CKMB,c Tn I and myoglobin before and after treatment(P>0.05).Conclusions Compared with the traditional myocardial biomarkers,hs-c Tn T and H-FABP are more sensitive to myocardial damage and could guide early clinical intervention in patients with acute exacerbation of COPD.